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AdipoGen Life Sciences
Cercosporin
160
CHF
CHF 160.00
In stock
AG-CN2-0111-M0011 mgCHF 160.00
AG-CN2-0111-M0055 mgCHF 590.00
| Product Details | |
|---|---|
| Synonyms | NSC 153111 |
| Product Type | Chemical |
| Properties | |
| Formula |
C29H26O10 |
| MW | 534.5 |
| CAS | 35082-49-6 |
| Source/Host Chemicals | Isolated from Cercospora sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Dark red solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| InChi Key | DGAZLNHJYDOWLG-UHFFFAOYSA-N |
| Smiles | COC1=C(CC(C)O)C2=C3C(CC(C)O)=C(OC)C(=O)C4=C(O)C=C5OCOC6=C(C5=C34)C2=C(C(O)=C6)C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Phytotoxin [1, 4].
- Potent and specific PKC inhibitor. Competes for the phorbol binding site [2, 3, 6].
- Anticancer compound. Cytotoxic [5, 6, 7].
- Antiproliferative [5, 6].
- Antiparasitic [7, 8].
- Antimicrobial [8].
- Photosensitizer, singlet oxygen 1O2 producer.
- Antimalaria
Product References
- Light-induced production of singlet oxygen and superoxide by the fungal toxin, cercosporin: M.E. Daub & R.P. Hangarter; Plant Physiol. 73, 855 (1983)
- Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C: T. Tamaoki, et al.; Adv. Second Messenger Phosphoprotein Res. 24, 497 (1990)
- Structural investigation of protein kinase C inhibitors: D. Barak, et al.; J. Mol. Struct. 230, 419 (1991)
- Cell surface redox potential as a mechanism of defense against photosensitizers in fungi: C.C. Sollod, et al.; Appl. Environ. Microbiol. 58, 444 (1992)
- Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization: A.L. Vandenbogaerde, et al.; Photochem. Photobiol. 67, 119 (1998)
- Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones: B.J. Morgan, et al.; JACS 131, 9413 (2009)
- Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity: E. Moreno, et al.; Nat. Prod. Commun. 6, 835 (2011)
- Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum: M. Kumarihamy, et al.; J. Nat. Prod. 75, 883 (2012)