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AdipoGen Life Sciences
Terpendole C
110
CHF
CHF 110.00
In stock
AG-CN2-0125-C250250 µgCHF 110.00
AG-CN2-0125-M0011 mgCHF 330.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C32H41NO5 |
| MW | 519.7 |
| CAS | 156967-65-6 |
| Source/Host Chemicals | Isolated from Albophoma yamanashiensis. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| InChi Key | WUOATFFODCBZBE-SHLFZZOBBH |
| Smiles | [H][C@]12CC3=C(NC4=CC=CC=C34)[C@]1(C)C1(C)CC[C@]3([H])O[C@H]4[C@@H](O[C@@H](OC4(C)C)C=C(C)C)[C@H]4O[C@@]34[C@]1(O)CC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor [1-3, 6].
- Tremorgenic [4, 5].
- Cholesteryl ester (CE) synthesis inhibitor [6, 7].
Product References
- Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
- Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
- Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 5 (1995)
- Isolation and structure elucidation of lolilline, a possible biosynthetic precursor of the lolitrem family of tremorgenic mycotoxins: S.C. Munday-Finch, et al.; J. Agric. Food Chem. 45, 199 (1997)
- Terpendole M, a novel indole-diterpenoid isolated from Lolium perenne infected with the endophytic fungus Neotyphodium lolii: W.A. Gatenby, et al.; J. Agric. Food Chem. 47, 1092 (1999)
- Selectivity of microbial acyl-CoA:cholesterol acyltransferase inhibitors toward isozymes: T. Ohshiro, et al.; J. Antibiot. (Tokyo) 60, 43 (2007)
- Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)
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