AdipoGen Life Sciences

Terpendole C

Name: Terpendole C
Brand: AdipoGen Life Sciences
SKU: AG-CN2-0125
Price: 330.00 CHF
Availability: InStock

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AG-CN2-0125-C250250 µgCHF 110.00

AG-CN2-0125-M0011 mgCHF 330.00

Specifications / Handling

More Information
Product Details
Product Type	Chemical
Properties
Formula	C₃₂H₄₁NO₅
MW	519.7
CAS	156967-65-6
Source/Host Chemicals	Isolated from Albophoma yamanashiensis.
Purity Chemicals	≥95% (HPLC)
Appearance	Off-white solid.
Solubility	Soluble in DMSO, ethanol or methanol.
InChi Key	WUOATFFODCBZBE-SHLFZZOBBH
Smiles	[H][C@]12CC3=C(NC4=CC=CC=C34)[C@]1(C)C1(C)CC[C@]3([H])O[C@H]4[C@@H](O[C@@H](OC4(C)C)C=C(C)C)[C@H]4O[C@@]34[C@]1(O)CC2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 3 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor [1-3, 6].
Tremorgenic [4, 5].
Cholesteryl ester (CE) synthesis inhibitor [6, 7].

Product-specific References

Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 5 (1995)
Isolation and structure elucidation of lolilline, a possible biosynthetic precursor of the lolitrem family of tremorgenic mycotoxins: S.C. Munday-Finch, et al.; J. Agric. Food Chem. 45, 199 (1997)
Terpendole M, a novel indole-diterpenoid isolated from Lolium perenne infected with the endophytic fungus Neotyphodium lolii: W.A. Gatenby, et al.; J. Agric. Food Chem. 47, 1092 (1999)
Selectivity of microbial acyl-CoA:cholesterol acyltransferase inhibitors toward isozymes: T. Ohshiro, et al.; J. Antibiot. (Tokyo) 60, 43 (2007)
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)

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