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AdipoGen Life Sciences
Terpendole E
95
CHF
CHF 95.00
In stock
AG-CN2-0127-C250250 µgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | 1'α-Hydroxy-Paspaline |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H39NO3 |
| MW | 437.6 |
| CAS | 167427-23-8 |
| Source/Host Chemicals | Isolated from Albophoma yamanashiensis. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. |
| InChi Key | SVYIMXYKHRBHSG-CDIJYFRTBB |
| Smiles | [H][C@]12CC3=C(NC4=CC=CC=C34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H](C[C@@H](O)[C@@]3(C)C1([H])CC2)C(C)(C)O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 2].
- Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) inhibitor [3-7].
- Specific M phase inhibitor [4].
Product References
- Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
- Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
- A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5: J. Nakazawa, et al.; Chem. Biol. 10, 131 (2003)
- Development and application of bioprobes for Mammalian cell cycle analyses: H. Osada; Curr. Med. Chem. 10, 727 (2003) (Review)
- Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly: C. Jiang, et al.; J. Mol. Model 13, 987 (2007)
- A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues: F. Churruca, et al.; Org. Lett. 12, 2096 (2010)
- Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds: S. Oishi, et al.; J. Med. Chem. 53, 5054 (2010)
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