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AdipoGen Life Sciences
Curvularin
75
CHF
CHF 75.00
In stock
AG-CN2-0147-M0011 mgCHF 75.00
AG-CN2-0147-M0055 mgCHF 300.00
| Product Details | |
|---|---|
| Synonyms | (S)-Curvularin; NSC 166071 |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H20O5 |
| MW | 292.3 |
| CAS | 10140-70-2 |
| Source/Host Chemicals | Isolated from Penicillium sp. FKI-1938 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in ethanol, methanol, DMSO, dioxane or pyridine. Insoluble in water, hexane, benzene or chloroform. |
| InChi Key | VDUIGYAPSXCJFC-JTQLQIEISA-N |
| Smiles | C[C@H]1CCCCCC(=O)C2=C(O)C=C(O)C=C2CC(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- Antiprotozoal [1].
- Antifungal and phytotoxic compound [1, 6].
- Anti-inflammatory [7].
- TGF-β signaling inhibitor [8]
- Anticancer compound [2, 9].
- Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII) [4, 5].
- Cell division inhibitor [3].
- Acetylcholinesterase (AChE) inhibitor [9].
Product References
- Antimicrobial properties of fungal macrolide antibiotics: V. Betina & D. Micekova; Z. Allg. Mikrobiol. 12, 355 (1972)
- Curvularin from Penicillium baradicum Baghdadi NRRL 3754, and biological effects: R.F. Vesonder, et al.; J. Environ. Sci. Health 11, 289 (1976)
- Structural study of curvularin, a cell division inhibitor: E.L. Ghisalberti, et al.; Austral. J. Chem. 46, 571 (1993)
- Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003)
- Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues: S. Elzner, et al.; ChemMedChem 3, 924 (2008)
- Isolation and Difference in Anti-Staphylococcus aureus Bioactivity of Curvularin Derivates from Fungus Eupenicillium sp.: L.W. Xie, et al.; Appl. Biochem. Biotechnol. 159, 284 (2009)
- The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis: N. Schmidt, et al.; J. Pharmacol. Exp. Ther. 343, 106 (2012)
- Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone: K. Rudolph, et al.; Cytokine 61, 285 (2013)
- Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India: C.G. Kumar, et al.; SpringerPlus 2, 122 (2013)
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