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AdipoGen Life Sciences
10,11-Dehydrocurvularin
140
CHF
CHF 140.00
In stock
AG-CN2-0165-M0011 mgCHF 140.00
AG-CN2-0165-M0055 mgCHF 560.00
| Product Details | |
|---|---|
| Synonyms | α,β-Dehydrocurvularin |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H18O5 |
| MW | 290.3 |
| CAS | 1095588-70-7 |
| Source/Host Chemicals | Isolated from Aspergillus sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in ethanol, methanol or DMSO. |
| InChi Key | AVIRMQMUBGNCKS-OAQKJQOQSA-N |
| Smiles | C[C@H]1CCC\C=C\C(=O)C2=C(CC(=O)O1)C=C(O)C=C2O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1, 2, 6].
- Antifungal [6].
- Nematicidal [4].
- Phytotoxic [3].
- TGF-β signaling inhibitor [9]
- Anticancer compound [5, 6, 8, 10].
- Strong activator of the heat shock response [8].
- Inhibitor of the appressorium formation of M. grisea [7]
- Inhibitor of NLRP3 inflammasome activation
Product References
- Curvularin. Part V. The compound C16H18O5, αβ-dehydrocurvularin: H.D. Munro, et al.; J. Chem. Soc. C 1967, 947 (1967)
- Isolation of alpha,beta-dehydrocurvularin from Aspergillus aureofulgens: O. Caputo & F. Viola; Planta Med. 31, 31 (1977)
- Brefeldin A and alpha,beta-dehydrocurvularin, two phytotoxins from Alternaria zinniae, a biocontrol agent of Xanthium occidentale: M. Vurro, et al.; Plant Sci. 138, 67 (1998)
- Betagamma-dehydrocurvularin and related compounds as nematicides of Pratylenchus penetrans from the fungus Aspergillus sp.: M. Kusano, et al.; Biosci. Biotechnol. Biochem. 67, 1413 (2003)
- Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants: J. He, et al.; J. Nat. Prod. 67, 1985 (2004)
- Isolation and difference in anti-Staphylococcus aureus bioactivity of curvularin derivates from fungus Eupenicillium sp.: L.W. Xie, et al.; Appl. Biochem. Biotechnol. 159, 284 (2009)
- Alternariol monomethyl ether and α, β-Dehydrocurvularin from endophytic Fungi Alternaria spp. inhibit appressorium formation of Magnaporthe grisea: Y.T. Jeon, et al.; J. Kor. Soc. Appl. Biol. Chem. 53, 39 (2010)
- Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus: Y. Xu, et al.; Appl. Environ. Microbiol. 79, 2038 (2013)
- Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone: K. Rudolph, et al.; Cytokine 61, 285 (2013)
- Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India: C.G. Kumar, et al.; Springerplus 2, 122 (2013)
- 10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation: Q. Zhao, et al.; Chin. J. Nat. Med. 21, 163 (2023)
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