AdipoGen Life Sciences

Actinonin

CHF 135.00
In stock
AG-CN2-0161-M0055 mgCHF 135.00
AG-CN2-0161-M02525 mgCHF 540.00
More Information
Product Details
Synonyms (-)-Actinonin; CONA 57; Ro 06-1467
Product Type Chemical
Properties
Formula

C19H35N3O5

MW 385.5
CAS 13434-13-4
RTECS RG9900700
Source/Host Chemicals Synthetic.
Purity Chemicals >97.0% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO or ethanol.
InChi Key XJLATMLVMSFZBN-UHFFFAOYSA-N
Smiles CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Antibiotic.
  • Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor.
  • Potent peptide deformylase (PDF) inhibitor.
  • Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14.
  • Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo.
  • Apoptosis inducer.
  • Meprin A inhibitor.
Product References
  1. Actinonin: an antibiotic substance produced by an actinomycete: J.J. Gordon, et al.; Nature 195, 701 (1962)
  2. Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. 38, 1629 (1985)
  3. Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987)
  4. Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998)
  5. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000)
  6. A new human peptide deformylase inhibitable by actinonin: M.D. Lee, et al.; Biochem. Biophys. Res. Comm. 312, 309 (2003)
  7. Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2004)
  8. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004)
  9. Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats: J. Takayama, et al.; Eur. J. Pharmacol. 581, 157 (2007) 
  10. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis: Z. Whang, et al.; Shock 35, 141 (2011)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.