Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Actinonin
135
CHF
CHF 135.00
In stock
AG-CN2-0161-M0055 mgCHF 135.00
AG-CN2-0161-M02525 mgCHF 540.00
| Product Details | |
|---|---|
| Synonyms | (-)-Actinonin; CONA 57; Ro 06-1467 |
| Product Type | Chemical |
| Properties | |
| Formula |
C19H35N3O5 |
| MW | 385.5 |
| CAS | 13434-13-4 |
| RTECS | RG9900700 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | >97.0% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | XJLATMLVMSFZBN-UHFFFAOYSA-N |
| Smiles | CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor.
- Potent peptide deformylase (PDF) inhibitor.
- Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14.
- Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo.
- Apoptosis inducer.
- Meprin A inhibitor.
Product References
- Actinonin: an antibiotic substance produced by an actinomycete: J.J. Gordon, et al.; Nature 195, 701 (1962)
- Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. 38, 1629 (1985)
- Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987)
- Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998)
- Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000)
- A new human peptide deformylase inhibitable by actinonin: M.D. Lee, et al.; Biochem. Biophys. Res. Comm. 312, 309 (2003)
- Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2004)
- Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004)
- Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats: J. Takayama, et al.; Eur. J. Pharmacol. 581, 157 (2007)
- Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis: Z. Whang, et al.; Shock 35, 141 (2011)
Related Products
