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AdipoGen Life Sciences
Roridin E
80
CHF
CHF 80.00
In stock
AG-CN2-0176-C250250 µgCHF 80.00
AG-CN2-0176-M0011 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | Satratoxin D; 2',3'-Didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxy-ethyl)verrucarin A |
| Product Type | Chemical |
| Properties | |
| Formula |
C29H38O5 |
| MW | 514.6 |
| CAS | 16891-85-3 |
| RTECS | YX9821500 |
| Source/Host Chemicals | Isolated from fungus Trichoderma sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in ethanol, methanol or DMSO (all 1mg/ml). |
| InChi Key | KEEQQEKLEZRLDS-ALFAKORJSA-N |
| Smiles | [H]C12[C@@]3([C@]4(C)[C@]5(CO5)[C@](C[C@H]4OC(/C=C\C=C\[C@](OCC/C(C)=C/C(OC3)=O)([H])C(O)C)=O)([H])O2)CCC(C)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin. Implicated in human and animal toxicosis.
- Potent cytotoxic and antiproliferative agent against cancer cell lines.
- Potent antimalarial agent.
- Antifungal, antibiotic, phototoxic and cytostatic agent.
- Antiviral against arenavirus Junin (JUNV).
Product References
- Structure of the antibiotic Roridin E: P. Traxler, et al.; Helv. Chim. Acta 53, 2071 (1970)
- Effects of macrocyclic trichothecene mycotoxins on the murine immune system: B.J. Hughes, et al.; Arch. Environ. Contam. Toxicol. 18, 388 (1989)
- Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria: M. Isaka, et al.; J. Nat. Prod. 62, 329 (1999)
- Phytotoxicity and mammalian cytotoxicity of macrocyclic trichothecene mycotoxins from Myrothecium verrucaria: H.K. Abbas, et al.; Phytochem. 59, 309 (2002)
- Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia: C.C. Garcia, et al.; Planta Med. 68, 209 (2002)
- 12'-Hydroxyl group remarkably reduces Roridin E cytotoxicity: T. Oda, et al.; Mycosciences 51, 317 (2010)
- Isolation and characterization of roridin E: C.D. Ridge, et al.; MRC 55, 337 (2017)
- Preparative separation and purification of trichothecene mycotoxins from the marine fungus Fusarium sp. LS68 by high-speed countercurrent chromatography in stepwise elution mode: Y. Liu, et al.; Mar. Drugs 16, 73 (2018)
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