AdipoGen Life Sciences

Roridin E

CHF 80.00
In stock
AG-CN2-0176-C250250 µgCHF 80.00
AG-CN2-0176-M0011 mgCHF 240.00
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Product Details
Synonyms Satratoxin D; 2',3'-Didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxy-ethyl)verrucarin A
Product Type Chemical
Properties
Formula

C29H38O5

MW 514.6
CAS 16891-85-3
RTECS YX9821500
Source/Host Chemicals Isolated from fungus Trichoderma sp.
Purity Chemicals ≥95% (HPLC)
Appearance Off-white solid.
Solubility Soluble in ethanol, methanol or DMSO (all 1mg/ml).
InChi Key KEEQQEKLEZRLDS-ALFAKORJSA-N
Smiles [H]C12[C@@]3([C@]4(C)[C@]5(CO5)[C@](C[C@H]4OC(/C=C\C=C\[C@](OCC/C(C)=C/C(OC3)=O)([H])C(O)C)=O)([H])O2)CCC(C)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Mycotoxin. Implicated in human and animal toxicosis.
  • Potent cytotoxic and antiproliferative agent against cancer cell lines.
  • Potent antimalarial agent.
  • Antifungal, antibiotic, phototoxic and cytostatic agent.
  • Antiviral against arenavirus Junin (JUNV).
Product References
  1. Structure of the antibiotic Roridin E: P. Traxler, et al.; Helv. Chim. Acta 53, 2071 (1970)
  2. Effects of macrocyclic trichothecene mycotoxins on the murine immune system: B.J. Hughes, et al.; Arch. Environ. Contam. Toxicol. 18, 388 (1989)
  3. Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria: M. Isaka, et al.; J. Nat. Prod. 62, 329 (1999)
  4. Phytotoxicity and mammalian cytotoxicity of macrocyclic trichothecene mycotoxins from Myrothecium verrucaria: H.K. Abbas, et al.; Phytochem. 59, 309 (2002)
  5. Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia: C.C. Garcia, et al.; Planta Med. 68, 209 (2002)
  6. 12'-Hydroxyl group remarkably reduces Roridin E cytotoxicity: T. Oda, et al.; Mycosciences 51, 317 (2010)
  7. Isolation and characterization of roridin E: C.D. Ridge, et al.; MRC 55, 337 (2017) 
  8. Preparative separation and purification of trichothecene mycotoxins from the marine fungus Fusarium sp. LS68 by high-speed countercurrent chromatography in stepwise elution mode: Y. Liu, et al.; Mar. Drugs 16, 73 (2018) 
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