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AdipoGen Life Sciences
Asiatic acid
60
CHF
CHF 60.00
In stock
AG-CN2-0400-M0055 mgCHF 60.00
AG-CN2-0400-M02525 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | 2α,23-Dihydroxyursolic acid; Dammarolic acid; NSC166063 |
| Product Type | Chemical |
| Properties | |
| Formula |
C30H48O5 |
| MW | 488.7 |
| CAS | 464-92-6 |
| Source/Host Chemicals | Isolated from Centella asiatica. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | JXSVIVRDWWRQRT-UYDOISQJSA-N |
| Smiles | [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)[C@@]2(C)CO |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Apoptosis inducer [1, 3].
- Cell cycle arrest inducer [1].
- Anticancer compound [1, 5]
- Antioxidant. Hepatoprotective [2]. Inhibits TGF-β/Smad-mediated fibrogenesis [12].
- Stimulates wound healing [4].
- Anti-diabetic. Glycogen phosphorylase inhibitor [6].
- Neuroprotective [13]. Modulates multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance. Down regulates BACE1 and increases ADAM10 maturation [7].
- Anti-hyperglycemic compound [8, 14].
- Anti-inflammatory and antinociceptive compound [9].
- Antiangiogenic [10].
- Acetylcholinesterase (AChE) inhibitor [11].
- PPARγ inhibitor through a C/EBPβ-independent mechanisms [15].
- Anti-osteoporotic. Inhibits adipogenic differentiation of bone marrow stromal cells (BMSC) [15].
Product References
- Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells: Y.L. Hsu, et al.; J. Pharmacol. Exp. Ther. 313, 333 (2005)
- Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice: J. Gao, et al.; J. Pharm. Pharmacol. 58, 227 (2006)
- Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid: G.M. Gurfinkel, et al.; Apoptosis 11, 1463 (2006)
- Structure-activity relationship study of asiatic acid derivatives for new wound healing agent: B.S. Jeong; Arch. Pharm. Res. 29, 556 (2006)
- Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade: X.L. Tang, et al.; Biol. Pharm. Bull. 32, 1399 (2009)
- Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases: L. Zhang, et al.; Chem. Biodivers. 6, 864 (2009)
- Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance: S.P. Patil, et al.; J. Nat. Prod. 73, 1196 (2010)
- Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats: J. Liu, et al.; Diabetes Metab. Res. Rev. 26, 448 (2010)
- Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice: S.S. Huang, et al.; Evid. Based Complement Alternat. Med. 2011, 895857 (2011)
- Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models: C.V. Kavitha, et al.; PLoS One 6, e22745 (2011)
- Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity: M.N. Nasir, et al.; Phytomedicine 19, 311 (2012)
- Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro: L.X. Tang, et al.; PLoS One 7, e31350 (2012)
- Asiatic acid attenuates infarct volume, mitochondrial dysfunction, and matrix metalloproteinase-9 induction after focal cerebral ischemia: K.Y. Lee, et al.; Stroke 43, 1632 (2012)
- Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats: V. Ramachandran & R. Saravanan; Phytomedicine 20, 230 (2013)
- Asiatic Acid Inhibits Adipogenic Differentiation of Bone Marrow Stromal Cells: Z.W. Li, et al.; Cell Biochem. Biophys. 68, 437 (2014)
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