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AdipoGen Life Sciences
Meglumine
35
CHF
CHF 35.00
In stock
AG-CN2-0413-G0011 gCHF 35.00
AG-CN2-0413-G0055 gCHF 90.00
| Product Details | |
|---|---|
| Synonyms | N-Methyl-D-glucamine; NSC52907; NSC7391; 1-Deoxy-1-methylaminosorbitol |
| Product Type | Chemical |
| Properties | |
| Formula |
C7H17NO5 |
| MW | 195.2 |
| Merck Index | 14: 6078 |
| CAS | 6284-40-8 |
| Source/Host Chemicals | Synthetic. Amino sugar derived from sorbitol. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in DMSO or water. Slightly soluble in ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | MBBZMMPHUWSWHV-UHFFFAOYSA-N |
| Smiles | [H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)CNC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances.
- Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium.
- Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as diatrizoate meglumine and iodipamide meglumine.
- Examples of meglumine-combined drugs are flunixin meglumine (used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis).
Product References
- Ternary amorphous composites of celecoxib, poly(vinyl pyrrolidone) and meglumine with enhanced solubility: P. Gupta & A.K. Bansal; Pharmazie 60, 830 (2005)
- Modeling of drug release from celecoxib-PVPmeglumine amorphous system: P. Gupta & A.K. Bansal; PDA. J. Pharm. Sci. Technol. 59, 346 (2005)
- Molecular interactions in celecoxib-PVPmeglumine amorphous system: P. Gupta & A.K. Bansal; J. Pharm. Pharmacol. 57, 303 (2005)
- Enhanced oral delivery of antimony from meglumine antimoniate/b-cyclodextrin nanoassemblies: F. Frezard, et al.; Int. J. Pharm. 347, 102 (2008)
- Generation of formaldehyde by pharmaceutical excipients and its absorption by meglumine: M. Fujita, et al.; Chem. Pharm. Bull. 57, 1096 (2009)
- Stabilization by meglumine of an amine compound degraded by formaldehyde in tablets: M. Fujita, et al.; Int. J. Pharm. 386, 195 (2010)