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AdipoGen Life Sciences
Ionomycin (free acid)
85
CHF
CHF 85.00
In stock
AG-CN2-0416-M0011 mgCHF 85.00
AG-CN2-0416-M0055 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Antibiotic SQ 23377; EM 94 |
| Product Type | Chemical |
| Properties | |
| Formula |
C41H72O9 |
| MW | 709.0 |
| CAS | 56092-81-0 |
| RTECS | NO0600000 |
| Source/Host Chemicals | Isolated from Streptomyces conglobatus. |
| Purity Chemicals | ≥98% (HPLC, TLC) |
| Appearance | Waxy yellow to colorless solid. |
| Solubility | Soluble in methanol (2mg/ml), ethanol (10mg/ml) or DMSO (10mg/ml). |
| InChi Key | PGHMRUGBZOYCAA-ZRDXXTDTSA-N |
| Smiles | [H][C@@]1(CC[C@](C)(O1)[C@@H](C)O)[C@]1(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C\C[C@@H](C)C[C@@H](C)C(\O)=C\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators [2, 3].
- Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+ [3, 9].
- Apoptosis inducer [4, 7]. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination [6].
- Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA [5, 8].
- ADAM10 agonist [10].
- Potent inducer of shedding CXCL16 [10].
- TREK-1 channels inhibitor [11].
- PPARγ ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes [12].
Product References
- Ionomycin, a new polyether antibiotic: W.C. Liu, et al.; J. Antibiot. 31, 815 (1978)
- Characterization of ionomycin as a calcium ionophore: C. Liu & T.E. Hermann; J. Biol. Chem. 253, 5892 (1978)
- Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria: R.F. Kauffman, et al.; J. Biol. Chem. 255, 2735 (1980)
- Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes: D.M. Ojcius, et al.; Exp. Cell Res. 197, 43 (1991)
- Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d'Angeac, et al.; J. Cell. Physiol. 154, 44 (1993)
- Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res. 652, 65 (1994)
- Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery, et al.; J. Immunol. 155, 3297 (1995)
- Flow cytometric analysis of intracellular IFN-γ, IL-4 and IL-10 in CD3+4+ T-cells from rat spleen: E.M. Caraher, et al.; J. Immunol. Methods 244, 29 (2000)
- The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43,15956 (2004)
- Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin: F. Scholz, et al.; J. Invest. Dermatol. 127, 1444 (2007)
- Calcium-dependent inhibition of adrenal TREK-1 channels by angiotensin II and ionomycin: J.J. Enyeart, et al.; Am. J. Physiol. Cell Physiol. 301, C619 (2011)
- Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes: W. Zheng, et al.; Diabetologia 56, 401 (2013)
- CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A: A. Sharma, et al.; PLoS One 13, e0196512 (2018)
- Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction: B. Mallavia, et al.; Am. J. Respir. Cell Mol. Biol. 62, 364 (2020)
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