30 CHF CHF 30.00
AG-CN2-0426-G0011 gCHF 30.00
AG-CN2-0426-G0055 gCHF 80.00
|Synonyms||Methylenesuccinic acid; 2-Propene-1,2-dicarboxylic acid|
|Solubility||Soluble in water, ethanol or methanol.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
|Handling Advice||Keep cool and dry.|
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
- Mammalian antibacterial metabolite.
- Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth [1, 4].
- Antimicrobial. Antibacterial [1, 3, 4].
- Inhibits the growth of bacteria expressing isocitrate lyase [1, 3, 4].
- Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat .
- Might be involved in the regulation of metabolism .
- One of the most highly induced metabolites in activated macrophages.
- Exerts anti-inflammatory effects in vitro and in vivo.
- Regulates succinate levels by inhibiting succinate dehydrogenase (SDH).
- Regulates mitochondrial respiration and cytokine production.
- Might induce inflammasome activation and consequently IL-1β secretion by generating ROS.
- Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera: B.A. McFadden & S. Purohit; J. Bacteriol. 131, 136 (1977)
- Itaconate reduces visceral fat by inhibiting fructose 2,6-bisphosphate synthesis in rat liver: A. Sakai, et al.; Nutrition 20, 997 (2004)
- Itaconic acid is a mammalian metabolite induced during macrophage activation: C.L. Strelko, et al.; JACS 133, 16386 (2011)
- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production: A. Michelucci, et al.; PNAS 110, 7820 (2013)
- Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation: V. Lampropoulou, et al.; Cell Metab. 24, 158 (2016)
- Food fight: Role of itaconate and other metabolites in antimicrobial defense: H.H. Luan & R. Medzhitov; Cell Metab. 24, 379 (2016)
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1: E.L. Mills, et al.; Nature 556, 113 (2018)