Aloesin

More Information
Product Details
Synonyms	Aloeresin B
Product Type	Chemical
Properties
Formula	C₁₉H₂₂O₉
MW	394.4
CAS	30861-27-9
Source/Host Chemicals	Isolated from Aloe vera.
Purity Chemicals	≥98% (HPLC)
Appearance	Pale yellow to brown sticky solid.
Solubility	Soluble in DMSO or ethanol.
Identity	Determined by ¹H-NMR.
InChi Key	HKIKAXXIWJHWLY-ZIIYPAMZSA-N
Smiles	CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2O1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

C-glycosylated chromone compound.
Tyrosinase inhibitor. Inhibits melanin production.
Inhibitor of hyperpigmentation.
Antioxidant. Free radical scavenger.
Anti-inflammatory compound.
Shown to up-regulate cyclin E/CDK2 kinase activity.
Hepatoprotective. Stimulates cell proliferation.
Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.

Product References

Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997)
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002)
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002)
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002)
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005)
Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction: H.A. El-Shemy, et al.; Curr. Med. Chem. 17, 129 (2010)
UP780, a chromone-enriched aloe composition improves insulin sensitivity: M. Yimam, et al.; Metab. Syndr. Relat. Disord. 11, 267 (2013)
Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model: M. Yimam, et al.; Diabetol. Metab. Syndr. 6, 61 (2014)
Phytochemical constituents and in vitro radical scavenging activity of different Aloe species: L. Pucini, et al.; Food Chem. 170, 501 (2014)

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