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AdipoGen Life Sciences
Emodin
60
CHF
CHF 60.00
In stock
AG-CN2-0457-M05050 mgCHF 60.00
AG-CN2-0457-M250250 mgCHF 180.00
| Product Details | |
|---|---|
| Synonyms | Emodol; Frangulic acid; Archin; NSC 622947; NSC 408120; 1,3,8-Trihydroxy-6-methylanthraquinone; Schuttgelb |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10O5 |
| MW | 270.2 |
| Merck Index | 14: 3561 |
| CAS | 518-82-1 |
| RTECS | CB7920600 |
| Source/Host Chemicals | Isolated from Polygonum cuspidatum. |
| Purity Chemicals | ≥98% |
| Appearance | Orange solid. |
| Solubility | Soluble in DMSO or 100% ethanol. Insoluble in water. |
| InChi Key | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(C(O)=C1)C(=O)C1=C(C=C(O)C=C1O)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- p56lck protein kinase inhibitor.
- Competitive casein kinase II (CK2) inhibitor.
- Anticancer agent with apoptosis inducing with antiangiogenic activity.
- Antioxidant, vasorelaxant and neuroprotective agent.
- NF-κB activation inhibitor.
- Inflammasome inhibitor.
- Potent selective 11β-HSD1 inhibitor. Improves insulin sensitivity and lipid metabolism.
- Estrogen receptor ERα and ERβ inhibitor.
- Inhibits androgen receptor (AR) nuclear translocation and induces AR degradation.
- VEGFR2, FGFR-1, EGFR, PDGFR-β and Kit inhibitor.
- JAK2 inhibitor.
- Anti-diabetic agent.
- AMPK activator and PPARγ agonist. Adipogenesis inhibitor.
- P2X7 receptor antagonist.
- Wnt signaling & PI3K/Akt/GSK-3β pathway modulator.
Product References
- Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb: H.C. Huang, et al.; Eur. J. Pharmacol. 205, 289 (1991)
- Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum: H. Jayasuriya, et al.; J. Nat. Prod. 55, 696 (1992)
- Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells: A. Kumar, et al.; Oncogene 17, 913 (1998)
- Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor: H. Yim, et al.; Planta Med. 65, 9 (1999)
- Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity: H. Matsuda, et al.; Bioorg. Med. Chem. Lett. 11, 1839 (2001)
- Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9: G. Srinivas, et al.; Eur. J. Pharmacol. 473, 117 (2003)
- Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth: T.L. Cha, et al.; Cancer Res. 65, 2287 (2005)
- Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation: H.J. Kwak, et al.; Int. J. Cancer 118, 2711 (2006)
- Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor: A. Muto, et al.; Mol. Cancer Ther. 6, 987 (2007)
- Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin: S.J. Lee, et al.; Phytother. Res. 24, 308 (2010)
- Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity: T. Liu, et al.; Brain Res. 1347, 149 (2010)
- Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor: L. Liu, et al.; Eur. J. Pharmacol. 640, 15 (2010)
- Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice: Y. Feng, et al.; Br. J. Pharmacol. 161, 113 (2010)
- Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity: Z. Chen, et al.; J. Cell Biochem. 113, 3547 (2012)
- Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis: S.Z. Lin, et al.; PLoS One 7, e42146 (2012)
- The distinct mechanisms of the antitumor activity of emodin in different types of cancer: W.T. Wei, et al.; Oncol. Rep. 30, 2555 (2013) (Review)
- Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620: T. Pooja & D. Karunagaran; Eur. J. Pharmacol. 742, 55 (2014)
- Emodin induces neurite outgrowth through PI3K/Akt/GSK-3β-mediated signaling pathways in Neuro2a cells: S.J. Park, et al.; Neurosci. Lett. 588, 101 (2015)
- Anti-Inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation: J.W. Han, et al.; Int. J. Mol. Sci. 16, 8102 (2015)
- Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein: H. Min, et al.; PLoS One 12, e0187971 (2017)
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