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AdipoGen Life Sciences
Amorfrutin A
270
CHF
CHF 270.00
In stock
AG-CN2-0462-C500500 µgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | 2-Hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)-6-phenethylbenzoic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H24O4 |
| MW | 340.4 |
| CAS | 80489-90-3 |
| Source/Host Chemicals | Isolated from Amorpha fruticosa. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO, ethanol or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | CTNFTPUIYFUXBE-UHFFFAOYSA-N |
| Smiles | COC1=C(CC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antidiabetic agent.
- Potent and selective partial agonist of peroxisome proliferator-activated receptor γ (PPARγ), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARγ and micromolar binding to the isotypes PPARα and PPARβ/δ.
- Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity.
- Shows potent PPARγ-dependent anti-inflammatory activity.
- Potent NF-κB activation inhibitor by the suppression of IκBα degradation, p65 nuclear translocation and DNA-binding activity.
- Antimicrobial agent.
Product References
- Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa: L.A. Mitscher, et al.; Phytochemistry 20, 781 (1981)
- Amorfrutins are potent antidiabetic dietary natural products: C. Weidner, et al.; PNAS 109, 7257 (2012)
- Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor gamma: J.C. De Groot, et al.; J. Med. Chem. 56, 1535 (2013)
- Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products: H. Shi, et al.; Int. Immunopharmacol. 21, 56 (2014)
- Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review: L. Wang, et al.; Biochem. Pharmacol. 92, 73 (2014)
- Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties: L. Fuhr, et al.; J. Nat. Prod. 78, 1160 (2015)
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