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AdipoGen Life Sciences
Theacrine
80
CHF
CHF 80.00
In stock
AG-CN2-0466-M100100 mgCHF 80.00
AG-CN2-0466-G0011 gCHF 180.00
AG-CN2-0466-G0055 gCHF 420.00
AG-CN2-0466-G02525 gCHF 880.00
| Product Details | |
|---|---|
| Synonyms | NSC8809; Temorine; 1,3,7,9-Tetramethyluric acid; TetraMUA |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H12N4O3 |
| MW | 224.2 |
| CAS | 2309-49-1 |
| Source/Host Chemicals | Synthetic. Originally isolated from Theobroma grandiflorum. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water (20mg/ml). |
| InChi Key | QGDOQULISIQFHQ-UHFFFAOYSA-N |
| Smiles | CN1C(=O)N(C)C2=C1N(C)C(=O)N(C)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Purine alkaloid related to caffeine.
- Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo.
- Anti-inflammatory and antinociceptive compound.
- Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors.
- Shown to have potent sedative and hypnotic properties.
- Ameliorated learning and memory impairments caused by central fatigue. Shown to inhibit cAMP-specific PDE4 and cGMP-specific PDE5 activity in vivo and in vitro. Increased glucose level, decreased lactic acid concentration, reduced LDH activity and elevated the expressions of both GLUT1/3 in restraint-stressed mice.
- Can increase the solubility of aromatic systems in water.
- Ligand to bitter taste receptors Type 2 (TAS2R43 and TAS2R46).
Product References
- The solubilization of polycyclic aromatic hydrocarbons by purines: H. Weil-Malherbe; Biochem. J. 40, 351 (1946)
- 1,3,7,9-Tetramethyluric acid a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants; B.A. Kihlman; Mutat. Res. 39, 297 (1977)
- Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid: V.B. Bhat, et al.; Life Sci. 70, 381 (2001)
- Caffeine and other xanthines as cytochemical blockers and removers of heterocyclic DNA intercalators from chromatin: M.B. Lyles & I.L. Cameron; Cell Biol. Int. 26, 145 (2002)
- Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice: J.K. Xu, et al.; J. Asian Nat. Prod. Res. 9, 665 (2007)
- Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities: Y. Wang, et al.; Fitoterapia 81, 627 (2010)
- Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors: A.A. Feduccia, et al.; Pharmacol. Biochem. Behav. 102, 241 (2012)
- Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice: W.X. Li, et al.; J. Agric. Food Chem. 61, 6328 (2013)
- Comparing antioxidant capacity of purine alkaloids: A new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo: B. Tsoi, et al.; Food Chem. 176, 411 (2015)
- BitterMatch: Recommendation systems for matching molecules with bitter taste receptors: E. Margulis, et al. Inst. Biochem. Food Sci. Nutr. Univ. Jerusalem (2022)