AG-CN2-0471-C500500 µgCHF 140.00
|Source/Host Chemicals||Isolated from fungus Aspergillus sp.|
|Purity Chemicals||≥98% (HPLC)|
|Solubility||Soluble in DMSO or ethanol.|
|Identity||Determined by 1H-NMR.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Protect from light.|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Antibiotic. Exhibits broad activity against Gram-positive bacteria.
- Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml).
- Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells.
- Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.
- Viriditoxin production by Aspergillus viridi-nutans and related species: E.B. Lillehoj & M.S. Milburn; Appl. Microbiol. 26, 202 (1973)
- Metabolic products from Spicaria divaricata NRRL 5771: J. Jiu S. Mizuba; J. Antibiot. (Tokyo) 27, 760 (1974)
- Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria: D.T. Wong & R.L. Hamill; BBRC 71, 332 (1976)
- Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics: J. Wang, et al.; J. Biol. Chem. 278, 44424 (2003)
- Second-Generation Synthesis of (-)-Viriditoxin: C.I. Grove & J.T. Shaw; Synthesis 2012, 362 (2012)
- Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells: S. Kundu, et al.; Int. J. Oncol. 45, 2331 (2014)
- A twist of nature - the significance of atropisomers in biological systems: J.E. Smyth, et al.; Nat. Prod. Rep. 32, 1562 (2015)