AdipoGen Life Sciences

Cucurbitacin E

CHF 45.00
In stock
AG-CN2-0474-M0011 mgCHF 45.00
AG-CN2-0474-M0055 mgCHF 160.00
AG-CN2-0474-M02525 mgCHF 640.00
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Product Details
Synonyms Cuc E; α-Elaterin; α-Elaterine; NSC106399; BRN2343323
Product Type Chemical
Properties
Formula

C32H44O8

MW 556.7
CAS 18444-66-1
Source/Host Chemicals Isolated from Cucumis melo L.
Purity Chemicals ≥98% (HPLC)
Appearance Off-white powder.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
InChi Key NDYMQXYDSVBNLL-MUYMLXPFSA-N
Smiles [H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)\C=C\C(C)(C)OC(C)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site.
  • Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin).
  • Immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy.
  • Shown to induce apoptosis, autophagy and cell cycle arrest at G2/M. Inhibits tumor angiogenesis through Jak-STAT3 signaling pathway, suppresses cell migration and invasion, and inhibits NF-κB nuclear translocation.
  • Antioxidant and potential neuroprotective compound with potential neurodegenerative properties.
Product References
  1. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells: K.L. Duncan, et al.; Biochem. Pharmacol. 52, 1553 (1996)
  2. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities: T. Tannin-Spitz, et al.; BBRC 364, 181 (2007)
  3. Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament: K. Momma, et al.; Cytotechnology 56, 33 (2008)
  4. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway: Y. Dong, et al.; Carcinogenesis 31, 2097 (2010)
  5. Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells: W.W. Huang, et al.; Evid. Based Complement Alternat. Med. 2012, 952762 (2012)
  6. The natural product cucurbitacin E inhibits depolymerization of actin filaments: P.M. Soerensen, et al.; ACS Chem. Biol. 7, 1502 (2012)
  7. Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion: T. Zhang, et al.; Breast Cancer Res. Treat. 135, 445 (2012)
  8. Cucurbitacin E exhibits anti-inflammatory effect in RAW 264.7 cells via suppression of NF-κB nuclear translocation: J. Qiao, et al.; Inflamm. Res. 62, 461 (2013)
  9. Cucurbitacin E as inducer of cell death and apoptosis in human oral squamous cell carcinoma cell line SAS: C.M. Hung, et al.; Int. J. Mol. Sci. 14, 17147 (2013)
  10. Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons: A.M. Arel-Dubeau, et al.; Oxid. Med. Cell Longev. 2014, 425496 (2014)
  11. Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells: Y.C. Hsu, et al.; Cell Death Dis. 5, e1087 (2014)
  12. Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity: Q.B. Zha, et al.; PLoS One 10, e0124355 (2015)
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