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AdipoGen Life Sciences
Colistin sulfate (Ph. Eur. Grade)
45
CHF
CHF 45.00
In stock
AG-CN2-0512-M100100 mgCHF 45.00
AG-CN2-0512-G0011 gCHF 110.00
AG-CN2-0512-G0055 gCHF 440.00
| Product Details | |
|---|---|
| Synonyms | Polymyxin E; Belcomycin; Colimycin |
| Product Type | Chemical |
| Properties | |
| Formula |
2(C52H98N16O13) . 5(H2SO4) (unspec.) |
| MW | 2801.7 |
| CAS | 1264-72-8 |
| RTECS | TR1500000 |
| Source/Host Chemicals | Isolated from Bacillus polymyxa. |
| Purity Chemicals | >77% (Mixture, primarly Polymyxin E1 and Polymyxin E2). |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (50mg/ml). |
| Biological Activity |
Potency (dry basis) ≥19000U/mg |
| Other Product Data |
Specifications: |
| InChi Key | YKQOSKADJPQZHB-QNPLFGSASA-N |
| Smiles | CCC(C)CCCC(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](CCN)C(N[C@H](C(N[C@@H](CCN)C1=O)=O)CCNC([C@@H](NC([C@@H](NC([C@H](CCN)NC([C@@H](NC([C@H](N1)CC(C)C)=O)CC(C)C)=O)=O)CCN)=O)[C@@H](C)O)=O)=O)=O)=O)=O.O=S(O)(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Very potent polymyxin antibiotic.
- Has only one amino acid difference compared to polymyxin B.
- Antimicrobial.
- Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death.
- Used against multidrug-resistant Gram-negative bacterial infections.
Product References
- Antimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review)
- Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review)
- The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review)
- Update on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review)
- Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review)
- Polymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review)
- Colistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review)
- New information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review)
- Colistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review)
- A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms: S. Frisch, et al.; J. Antimicrob. Chemother. 76, 1472 (2021)
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