590 CHF CHF 590.00
AG-CN2-0514-M0011 mgCHF 590.00
|Synonyms||α-Gal-Cer (Dansylated); KRN7000 (Dansylated)|
|Purity Chemicals||≥95% (1H-NMR, 13C-NMR and TLC (CH2Cl2/MeOH 3:1)|
|Solubility||Soluble in pyridine and DMSO.|
|Identity||Identity determined by 1H-NMR and MS.|
|Other Product Data||
NOTE: This glycolipid compound can be challenging in terms of solubility. For further information on solubility of this compound, please refer to J.M.H. Cheng, et al.; Carbohydr. Res. 346, 914 (2011), Experimental Section 4.16.2.
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-20°C|
Aliquot into glass vials.
Keep cool and dry.
Protect from light.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Fluorescent α-GalCer derivative.
- Potent stimulator of invariant natural killer T (iNKT) cells similar to α-GalCer (determined by CD86 expression in DCs and B cells, and IL-2 production by iNKT cells). Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells.
- Used as a fluorescent marker for the uptake of the glycolipid by dendritic cells (DC's) in vitro and to better understand the mechanism of iNKT cell activation.
- Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6''-amino-6''-deoxy- galactosylceramides: X.-T. Zhou, et al.; Org. Lett. 4, 1267 (2002)
- An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells: J.M.H. Cheng, et al.; Carbohydr. Res. 346, 914 (2011)
- Trehalose diesters, lipoteichoic acids and alpha-GalCer: using chemistry to understand immunology: B.L. Stocker & M.S.M. Timmer; Carbohydr. Res. 389, 3 (2014)