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NOTE: This glycolipid compound can be challenging in terms of solubility. For further information on solubility of this compound, please refer to J.M.H. Cheng, et al.; Carbohydr. Res. 346, 914 (2011), Experimental Section 4.16.2.
Potent stimulator of invariant natural killer T (iNKT) cells similar to α-GalCer (determined by CD86 expression in DCs and B cells, and IL-2 production by iNKT cells). Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells.
Used as a fluorescent marker for the uptake of the glycolipid by dendritic cells (DC's) in vitro and to better understand the mechanism of iNKT cell activation.
Product References
Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6''-amino-6''-deoxy- galactosylceramides: X.-T. Zhou, et al.; Org. Lett. 4, 1267 (2002)
An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells: J.M.H. Cheng, et al.; Carbohydr. Res. 346, 914 (2011)
Trehalose diesters, lipoteichoic acids and alpha-GalCer: using chemistry to understand immunology: B.L. Stocker & M.S.M. Timmer; Carbohydr. Res. 389, 3 (2014)