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AdipoGen Life Sciences
(-)-Arctiin
30
CHF
CHF 30.00
In stock
AG-CN2-0532-M01010 mgCHF 30.00
AG-CN2-0532-M05050 mgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | Arctigenin-4-glucoside; NSC 315527 |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H34O11 |
| MW | 534.6 |
| CAS | 20362-31-6 |
| Source/Host Chemicals | Isolated from Arctium lappa. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | Colorless crystals. |
| Solubility | Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (1mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | XOJVHLIYNSOZOO-SWOBOCGESA-N |
| Smiles | O=C1OC[C@H](CC2=CC(OC)=C(OC)C=C2)[C@H]1CC3=CC(OC)=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=C3 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Metabolizes into (-)-Arctigenin (AG-CN2-0530).
- Multifunctional natural compound with photoprotective, anti-inflammatory, antidiabetic, antiproliferative and antiviral activities.
- Decreasing the production of nitric oxide and pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α and PGE2 through the inhibition of PI3K/AKT/NF-κB signaling pathway.
- Suppresses cyclin D1 protein expression in multiple types of human tumor cells.
- Inhibitor of HIV-I integrase.
- Inhibits adipogenesis in 3T3-L1 adipocytes through the inhibition of PPARγ and C/EBPα and the activation of AMPK signaling pathways.
- Photoprotective agent showing UVB protection in keratinocytes, which is mediated by miRNA responses and the suppression of UVB-induced cell death.
- Inhibitor of STAT3 phosphorylation at tyrosine 705 residue.
Product References
- Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa: M. Takasaki, et al.; Cancer Lett. 29, 158 (2000)
- Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria: L.H. Xie, et al.; Chem. Pharm. Bull. 51, 378 (2003)
- Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression: Y. Matsuzaki, et al.; Oncol. Rep. 19, 721 (2008)
- Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus: K. Hayashi, et al.; Biol. Pharm. Bull. 33, 1199 (2010)
- Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways: S. Lee, et al.; J. Inflamm. 8, 16 (2011)
- Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet: B. Min, et al.; Nutr. Res. Pract. 8, 655 (2014)
- Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes: H.J. Cha, et al.; Mol. Med. Rep. 10, 1363 (2014)
- Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways: J. Li, et al.; J. Pharmacol. Sci. 135, 97 (2017)
- Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L: Q. Gao, et al.; Acta Pharmacol. Sin. 39, 787 (2018)
- Arctiin Prevents LPS-Induced Acute Lung Injury via Inhibition of PI3K/AKT Signaling Pathway in Mice: B. Zhou, et al.; Inflammation 41, 2129 (2018)
- Arctiin is a pharmacological inhibitor of STAT3 phosphorylation at tyrosine 705 residue and potentiates bortezomib-induced apoptotic and anti-angiogenic effects in human multiple myeloma cells: J.H. Lee, et al.; Phytomedicine 55, 282 (2019)
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