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AdipoGen Life Sciences
Q-VE-OPh (Negative Control)
225
CHF
CHF 225.00
In stock
AG-CP3-0007-M0011 mgCHF 225.00
| Product Details | |
|---|---|
| Synonyms | Q-Val-Glu-OPh; pan-Caspase Inhibitor (Negative Control); N-(2-Quinolyl)-L-valyl-L-glutamyl-(2,6-difluorophenoxy) methylketone |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H27F2N3O6 |
| MW | 527.5 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥95% (TLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO. |
| InChi Key | AXCYQCBDFVOWSL-JWIMYKKASA-N |
| Smiles | CC(C)[C@H](NC(=O)C1=CC=C2C=CC=CC2=N1)C(=O)NC(CCC(O)=O)C(=O)COC1=C(F)C=CC=C1F |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, non-toxic negative control for the caspase inhibitor Q-VD-OPh (Prod. No. AG-CP3-0006).
- Stable in aqueous environment.
- Several folds less inhibitory activity than Q-VD-OPh.
- Perfect for both in vitro and in vivo studies.
Product References
- Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003)
- The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15, 1403 (2010)
- Q-VE-OPh, a Negative Control for O-Phenoxy-Conjugated Caspase Inhibitors: B. Southerland, et al.; J. Cell Death 3, 33 (2010)
- The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36, 884 (2012)