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AdipoGen Life Sciences
Z-Leu-Leu-Leu-B(OH)2 [MG-262]
80
CHF
CHF 80.00
In stock
AG-CP3-0024-C200200 µgCHF 80.00
AG-CP3-0024-M0011 mgCHF 190.00
AG-CP3-0024-M0055 mgCHF 660.00
| Product Details | |
|---|---|
| Synonyms | Z-LLL-B(OH)2; Proteasome Inhibitor III |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H42BN3O6 |
| MW | 491.4 |
| Sequence |
Z-Leu-Leu-Leu-B(OH)2 |
| CAS | 179324-22-2 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Solid lyophilized powder. |
| Solubility | Soluble in DMSO. |
| InChi Key | MWKOOGAFELWOCD-FKBYEOEOSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)B(O)O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome.
- Calpain and cathepsin inhibitor.
- Autophagy activator.
- Similar structure as MG-132 (AG-CP3-0011) but much higher potency.
Product References
- Down-regulation of Flt-1 gene expression by the proteasome inhibitor MG262: J. Mezquita, et al.; J. Cell. Biochem. 89, 1138 (2003)
- Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate: A.F. Kisselev, et al.; J. Biol. Chem. 281, 8582 (2006)
- Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease: H. Frase, et al.; Biochemistry 45, 8264 (2006)
- Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes: A Role for the Cytosolic AAA ATPase p97?: S. Faouzi, et al.; Biochemistry 46, 7793 (2007)
- Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment: P.G. Thomes, et al.; BBRC 417, 262 (2012)
- Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells: N. Tange, et al.; Biomed. Pharmacother. 128,110330 (2020)
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