Z-Leu-Leu-Nva-CHO [MG-115]

More Information
Product Details
Synonyms	Z-LLNva-CHO; Proteasome Inhibitor
Product Type	Chemical
Properties
Formula	C₂₅H₃₉N₃O₅
MW	461.6
Sequence	Z-Leu-Leu-Nva-aldehyde
CAS	133407-86-0
Purity Chemicals	≥95% (HPLC)
Appearance	Solid lyophilized powder.
Solubility	Soluble in DMSO.
Other Product Data	Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect.
InChi Key	QEJRGURBLQWEOU-FKBYEOEOSA-N
Smiles	[H]C(=O)[C@H](CCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome.
Calpain and cathepsin inhibitor.
Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway.
Autophagy activator.

Product References

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids: J. Adams, et al.; Bioorg. Med. Chem. Lett. 17, 333 (1998)
Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role: K. Yamauchi, et al.; FEBS J. 275, 1540 (2008)
Proteasome inhibition induces stress kinase dependent transport deficits-implications for Alzheimer's disease: L. Agholme, et al.; Mol. Cell Neurosci. 58, 29 (2014)

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