AdipoGen Life Sciences

Mazdutide

CHF 70.00

In stock

AG-CP3-0045-M0011 mgCHF 70.00

AG-CP3-0045-M0055 mgCHF 240.00

AG-CP3-0045-M02525 mgCHF 720.00

BULK available!
Research Use Only (RUO). NOT ALLOWED FOR USE IN HUMANS.

More Information
Product Details
Synonyms	LY3305677; LY-3305677; IBI362
Product Type	Chemical
Properties
Formula	C₂₁₀H₃₂₂N₄₆O₆₇
MW	4563.1
Sequence	H-His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-{diacid-C20-gamma-Glu-(AEEA)2-Lys}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
CAS	2259884-03-0
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	White powder.
Solubility	Soluble in water or DMSO (both 1mg/ml).
InChi Key	NCZIWZAVWHEUKM-SQZAUUIPSA-N
Smiles	O=C(N)CNC([C@H](CO)NC([C@H](CO)NC([C@H]1N(C(CNC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC7=CC=CC=C7)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC8=CNC=N8)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R.
Mazdutide is a synthetic peptide analog of the gut peptide hormone oxyntomodulin that reduces body weight in both Gcgr-/- and Glp1r-/- mice. Mazdutide binds human and mouse GCGR (Ki: 17.7nM and 15.9nM, respectively) and GLP-1R (Ki: 28.6nM and 25.1nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) and is designed enhancing energy expenditure and fat metabolism.
Mazdutide comprises a 33 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue at position 20. Due to this moiety, the compound is highly bound to albumin in the plasma which prolongs its half-life. It contains one non-coded amino acid residue (Aib, α-amino isobutyric acid) at position 2.

Product References

682-P: novel dual glucagon and glucagon-like peptide-1 receptor agonist LY3305677 improves glucose control, reduces body weight, and increases energy expenditure in mice: Y. Chen, et al.; Diabetes 70, 682-P (2021)
IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study: L. Ji, et al.; EClinicalMedicine 39, 101088 (2021)
The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases: T. Chen, et al.; J. Med. Chem. 65, 3685 (2022)
Use of mazdutide: P. An & H. Deng (Innovate Biologics) WO2022268174A1(2022)
A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes: H. Jiang, et al.; Nat. Commun. 13, 3613 (2022)
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity: L. Ji, et al.; Nat. Commun. 14, 8289 (2023)

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