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AdipoGen Life Sciences
H-8 . dihydrochloride
50
CHF
CHF 50.00
In stock
AG-CR1-0001-M01010 mgCHF 50.00
AG-CR1-0001-M05050 mgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H15N3O2S . 2HCl |
| MW | 265.3 . 72.9 |
| CAS | 113276-94-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol (slightly soluble). |
| InChi Key | RJJLZYZEVNCZIW-UHFFFAOYSA-N |
| Smiles | [Cl-].[Cl-].C[NH2+]CC[NH2+]S(=O)(=O)C1=CC=CC2=CN=CC=C12 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor [1, 2, 4].
- Myosin light chain kinase (MLCK) inhibitor [3].
- Tool to study protein crystal structure-inhibitor interactions [5].
Product References
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984)
- Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986)
- Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase: M. Hagiwara, et al.; Mol. Pharmacol. 31, 523 (1987)
- Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987)
- Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh, et al.; J. Biol. Chem. 271, 26157 (1996)