AdipoGen Life Sciences

Pifithrin-α · hydrobromide

CHF 65.00
In stock
AG-CR1-0004-M0055 mgCHF 65.00
AG-CR1-0004-M01010 mgCHF 110.00
AG-CR1-0004-M02525 mgCHF 220.00
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Product Details
Synonyms 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, Pfithrin alpha
Product Type Chemical
Properties
Formula

C16H18N2OS . HBr

MW 286.4 . 80.9
CAS 63208-82-2
Purity Chemicals ≥98% (HPLC + NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or 100% ethanol.
Identity Determined by 1H-NMR.
InChi Key HAGVCKULCLQGRF-UHFFFAOYSA-N
Smiles [Br].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • p53 inhibitor [1, 2]. 
  • Reversibly blocks p53-dependent transcriptional activation [2].
  • Tool to combat side effects of cancer therapy [3].
  • Apoptosis inhibitor [1, 2, 4].
Product References
  1. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999)
  2. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004)
  3. Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999)
  4. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002)
  5. Loss of Fragile X Protein FMRP Impairs Homeostatic Synaptic Downscaling through Tumor Suppressor p53 and Ubiquitin E3 Ligase Nedd4-2: K.Y. Lee, et al.; Hum. Mol. Genet. ahead of print (2018)
  6. Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation: D.C. Liu, et al.; PLoS Genetics 15, e1008364 (2019)
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