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AdipoGen Life Sciences
Pifithrin-α · hydrobromide
65
CHF
CHF 65.00
In stock
AG-CR1-0004-M0055 mgCHF 65.00
AG-CR1-0004-M01010 mgCHF 110.00
AG-CR1-0004-M02525 mgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, Pfithrin alpha |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H18N2OS . HBr |
| MW | 286.4 . 80.9 |
| CAS | 63208-82-2 |
| Purity Chemicals | ≥98% (HPLC + NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HAGVCKULCLQGRF-UHFFFAOYSA-N |
| Smiles | [Br].CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- p53 inhibitor [1, 2].
- Reversibly blocks p53-dependent transcriptional activation [2].
- Tool to combat side effects of cancer therapy [3].
- Apoptosis inhibitor [1, 2, 4].
Product References
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999)
- Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004)
- Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999)
- Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002)
- Loss of Fragile X Protein FMRP Impairs Homeostatic Synaptic Downscaling through Tumor Suppressor p53 and Ubiquitin E3 Ligase Nedd4-2: K.Y. Lee, et al.; Hum. Mol. Genet. ahead of print (2018)
- Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation: D.C. Liu, et al.; PLoS Genetics 15, e1008364 (2019)