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AdipoGen Life Sciences
Compound 34
125
CHF
CHF 125.00
In stock
AG-CR1-0007-C200200 µgCHF 125.00
AG-CR1-0007-M0011 mgCHF 375.00
| Product Details | |
|---|---|
| Synonyms | (2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzo[e][1,4]diazepin-3-yl)butyramide |
| Product Type | Chemical |
| Properties | |
| Formula |
C31H24F3N3O3 |
| MW | 543.5 |
| CAS | 564462-36-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO. |
| InChi Key | JFRCHOZGXWZLOQ-TZIIFLTASA-N |
| Smiles | OC[C@H]([C@H](C(=O)N[C@H]1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC=C2)C1=CC=C(F)C=C1)C1=CC=C(F)C(F)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, highly potent inhibitor of γ-secretase (IC50 = 0.06 nM) [1].
Product References
- Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement: I. Churcher, et al.; J. Med. Chem 46 2275 (2003)
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