AdipoGen Life Sciences

FK-866

CHF 55.00
In stock
AG-CR1-0011-M0011 mgCHF 55.00
AG-CR1-0011-M0055 mgCHF 120.00
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Product Details
Synonyms K 22.175; FK866; APO866; WK175; N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Product Type Chemical
Properties
Formula

C24H29N3O2

MW 391.5
CAS 658084-64-1
Purity Chemicals ≥98% (NMR)
Appearance White to yellow solid. (Tends to easily liquefy.)
Solubility Soluble in 100% ethanol, dimethylformamide (40 mg/ml) or DMSO (25 mg/ml); sparingly soluble in aqueous buffers.
InChi Key KPBNHDGDUADAGP-VAWYXSNFSA-N
Smiles O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Keep under inert gas.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Nampt/visfatin inhibitor [1].
  • Inhibitor of NAD+ biosynthesis [1].
  • Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1].
  • Apoptosis inducer [1].
  • Autophagy inducer [2].
  • Causes premature senescence [3].
  • Angiogenesis inhibitor [4].
Product References
  1. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003) 
  2. NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008) 
  3. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007) 
  4. Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003) 
  5. Nicotinamide phosphoribosyltransferase production in human spermatozoa is influenced by maturation stage: S. Riammer, et al.; Andrology 4, 1045 (2016)
  6. Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis: L. Brandl, et al.; Neoplasia 21, 974 (2019)
  7. A peroxisome deficiency–induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway: Y. Abe, et al.; J. Biol. Chem. 295, 5321 (2020)
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