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AdipoGen Life Sciences
FK-866
55
CHF
CHF 55.00
In stock
AG-CR1-0011-M0011 mgCHF 55.00
AG-CR1-0011-M0055 mgCHF 120.00
AG-CR1-0011-M02525 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | K 22.175; FK866; APO866; WK175; N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H29N3O2 |
| MW | 391.5 |
| CAS | 658084-64-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to yellow solid. (Tends to easily liquefy.) |
| Solubility | Soluble in 100% ethanol, dimethylformamide (40 mg/ml) or DMSO (25 mg/ml); sparingly soluble in aqueous buffers. |
| InChi Key | KPBNHDGDUADAGP-VAWYXSNFSA-N |
| Smiles | O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep under inert gas. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Nampt/visfatin inhibitor [1].
- Inhibitor of NAD+ biosynthesis [1].
- Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1].
- Apoptosis inducer [1].
- Autophagy inducer [2].
- Causes premature senescence [3].
- Angiogenesis inhibitor [4].
Product References
- FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003)
- NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008)
- Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007)
- Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003)
- Nicotinamide phosphoribosyltransferase production in human spermatozoa is influenced by maturation stage: S. Riammer, et al.; Andrology 4, 1045 (2016)
- Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis: L. Brandl, et al.; Neoplasia 21, 974 (2019)
- A peroxisome deficiency–induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway: Y. Abe, et al.; J. Biol. Chem. 295, 5321 (2020)