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AdipoGen Life Sciences
Ketanserin . tartrate
40
CHF
CHF 40.00
In stock
AG-CR1-0014-M01010 mgCHF 40.00
AG-CR1-0014-M05050 mgCHF 90.00
| Product Details | |
|---|---|
| Synonyms | 3-[2-[4-(4-Fluorobenzoyl)-1-piperdinyl)ethyl]-2,4(1H,3H)-quinazolinedione tartrate |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H22FN3O3 . C4H6O6 |
| MW | 395.4 . 150.1 |
| Merck Index | 14: 5296 |
| CAS | 83846-83-7 |
| RTECS | VA1411195 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO; slightly soluble in water (4 mg/ml) or 100% ethanol (3 mg/ml). |
| InChi Key | KMTLTEVOQLMYRS-UHFFFAOYSA-N |
| Smiles | [CH2]C#CC.OOOOOO.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=O)NC3=CC=CC=C3C2=O)CC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective 5-HT2A serotonin receptor antagonist [1].
- ATP-sensitive potassium channel inhibitor [2].
- hERG potassium channel blocker [3].
Product References
- Vascular activity of ketanserin (R 41 468), a selective 5-HT2 receptor antagonist: J.M. van Nueten, et al.; Arch. Int. Pharmacodyn. Ther. 250, 328 (1981)
- Ketanserin, a 5-HT2 antagonist, directly inhibits the ATP-sensitive potassium channel in mouse ventricular myocytes: J.M. Ju, et al.; J. Cardiovasc. Pharmacol. 47, 96 (2006)
- The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels: Q. Li, et al.; Br. J. Pharmacol. 155, 365 (2008)