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AdipoGen Life Sciences
DAPT
90
CHF
CHF 90.00
In stock
AG-CR1-0016-M0055 mgCHF 90.00
AG-CR1-0016-M02525 mgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tert.butyl ester |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H26F2N2O4 |
| MW | 432.5 |
| CAS | 208255-80-5 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane. |
| Other Product Data |
Stock solutions are stable for up to 3 months when stored at -20°C. |
| InChi Key | DWJXYEABWRJFSP-XOBRGWDASA-N |
| Smiles | C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H](C(=O)OC(C)(C)C)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable γ-secretase inhibitor (IC50 = 115 nM for total β-amyloid, IC50 = 200 nM for β-amyloid 1-42) [1].
- Reduces Aβ levels in vivo [2].
- Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD) [3].
- Does not inhibit persenilinase [4].
- Notch processing inhibitor [5].
- Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling [6].
- CDK5 activity inhibitor [7].
- Apoptosis enhancer [8].
- Inhibitor of slurp-like1 expression in the floor plate of the neural tube.
Product References
- Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain: H.F. Dovey, et al.; J. Neurochem. 76, 173 (2001)
- The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice: T.A. Lanz, et al.; J. Pharmacol. Exp. Ther. 305, 864 (2003)
- Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD: K. Gowrishankar, et al.; J. Cell. Sci. 117, 4099 (2004)
- Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase: W.A. Campbell, et al.; J. Neurochem. 85, 1563 (2003)
- A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish: A. Geling, et al.; EMBO Rep. 3, 688 (2002)
- The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling: T.Q. Crawford & H. Roelink; Dev. Dyn. 236, 886 (2007)
- The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins: J. Kanungo, et al.; J. Neurochem. 106, 2236 (2008)
- DAPT enhances the apoptosis of human tongue carcinoma cells: B.E. Grottklau, et al.; Int. J. Oral Sci. 1, 81 (2009)
- Developmental expression of the slurp-like1/ly2.3/ly97.3 and slurp-like2/ly2.2/ly97.2 genes during zebrafish early embryogenesis: A. Kawahara, et al.; Gene Expr. Pattern 30, 32 (2018)
- 3D Bioprinted Human Cortical Neural Constructs Derived from Induced Pluripotent Stem Cells: F. Salaris, et al.; J. Clin. Med. 8, 1595 (2019)
- Regulation and role of glycophagy in skeletal muscle energy metabolism: T.D. Heden, et al.; Autophagy ahead of print (2021)
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