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AdipoGen Life Sciences
SNC80
90
CHF
CHF 90.00
In stock
AG-CR1-0017-M0055 mgCHF 90.00
AG-CR1-0017-M02525 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide; NIH 10815 |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H39N3O2 |
| MW | 449.6 |
| CAS | 156727-74-1 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | White to off-white crystalline solid. |
| Solubility | Soluble in 100% ethanol, DMSO or dichloromethane. |
| InChi Key | KQWVAUSXZDRQPZ-UMTXDNHDSA-N |
| Smiles | [H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC(OC)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Highly selective and potent non-peptide δ-opioid receptor agonist [1-3].
- Mediates downregulation of the δ-opioid receptor [4].
- Shows antidepressant-like effects [5, 8].
- Modulates voltage-dependent sodium channels [6].
- Antinociceptive [7].
- Activates ATP-sensitive K+ channels [7].
- Enhances amphetamine-mediated dopamine efflux [9].
Product References
- Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4- [(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994)
- SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995)
- Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp|et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996)
- Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin: T. Okura, et al.; Eur. J. Pharmacol. 387, R11 (2000)
- Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents: A. Saitoh, et al.; J. Pharmacol. Sci. 95, 374 (2004)
- Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons: C. Remy, et al.; Neuropharmacology 47, 1102 (2004)
- Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels: D.F. Pacheco & I.D. Duarte; Eur. J. Pharmacol. 512, 23 (2005)
- Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model: A. Saitoh, et al.; Brain Res. 1208, 160 (2008)
- The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum: K.E. Bosse, et al.; Neuropharmacology 55, 755 (2008)