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AdipoGen Life Sciences
NU6102
65
CHF
CHF 65.00
In stock
AG-CR1-0020-M0011 mgCHF 65.00
AG-CR1-0020-M0055 mgCHF 195.00
| Product Details | |
|---|---|
| Synonyms | O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H22N6O3S |
| MW | 402.5 |
| CAS | 444722-95-6 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | OWXORKPNCHJYOF-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C1=CC=C(NC2=NC3=C(N=CN3)C(OCC3CCCCC3)=N2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor [1-3].
- 1'000-fold more potent than NU2058 [1].
- Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 μM), DYRK1A (IC50 = 0.9 μM), PDK1 (IC50 = 0.8 μM) and ROCK-II (IC50 = 0.6 μM) [1].
- Inhibits cell growth [1].
Product References
- Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002)
- N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004)
- Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)
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