NU6102

CHF 65.00
In stock
AG-CR1-0020-M0011 mgCHF 65.00
AG-CR1-0020-M0055 mgCHF 195.00
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Product Details
Synonyms O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine
Product Type Chemical
Properties
Formula C18H22N6O3S
MW 402.5
CAS 444722-95-6
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
InChi Key OWXORKPNCHJYOF-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor [1-3]. 
  • 1'000-fold more potent than NU2058 [1]. 
  • Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 μM), DYRK1A (IC50 = 0.9 μM), PDK1 (IC50 = 0.8 μM) and ROCK-II (IC50 = 0.6 μM) [1]. 
  • Inhibits cell growth [1].
Product References
  1. Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002) 
  2. N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004) 
  3. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)
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