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AdipoGen Life Sciences
Bisindolylmaleimide V
75
CHF
CHF 75.00
In stock
AG-CR1-0023-M0011 mgCHF 75.00
AG-CR1-0023-M0055 mgCHF 225.00
| Product Details | |
|---|---|
| Synonyms | Ro 31-6045; BIM V |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H15N3O2 |
| MW | 341.4 |
| CAS | 113963-68-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Red crystalline solid. |
| Solubility | Soluble in DMSO or methanol. |
| InChi Key | SWAWYMIKGOHZMR-UHFFFAOYSA-N |
| Smiles | CN1C(=O)C(C2=CNC3=CC=CC=C23)=C(C1=O)C1=CNC2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Negative control for protein kinase C (PKC) inhibitors [1, 2].
- S6K inhibitor [3].
- Necrosis inhibitor [4].
Product References
- Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992)
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991)
- Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling: N. Marmy-Conus, et al.; FEBS Lett. 519, 135 (2002)
- Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons: R. Asakai, et al.; Neurosci. Res. 44, 297 (2002)
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