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AdipoGen Life Sciences

BAY 43-9006

As low as CHF 20.00
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AG-CR1-0025-M0011 mgCHF 20.00
AG-CR1-0025-M0055 mgCHF 55.00
AG-CR1-0025-M02525 mgCHF 160.00
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Specifications / Handling

More Information
Product Details
Synonyms Sorafenib; N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
Product Type Chemical
Properties
Formula

C21H16ClF3N4O3
MW 464.8
CAS 284461-73-0
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
Identity Determined by 1H-NMR.
InChi Key MLDQJTXFUGDVEO-UHFFFAOYSA-N
Smiles CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet Download PDF Download PDF
Product Specification Sheet
Datasheet Download PDF Download PDF

Scientific Background Information

Product Description
  • Antitumor compound [1].
  • Broad-spectrum kinase inhibitor [2].
  • Raf kinase inhibitor [2, 3].
  • Apoptosis inducer [3, 4].
  • Cytostatic [5].
  • Angiogenesis inhibitor [2, 5].
  • Review [6].
Product-specific References
  1. BAY 43-9006: preclinical data: S. Wilhelm & D.S. Chien; Curr. Pharm. Des. 8, 2255 (2002)
  2. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005) 
  3. The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells: D.J. Panka, et al.; Cancer Res. 66, 1611 (2006) 
  4. The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007)
  5. BAY-43-9006 Bayer/Onyx: J.T. Lee & J.A. McCubrey; Curr. Opin. Investig. Drugs 4, 757 (2003)
  6. Sorafenib (BAY 43-9006): review of clinical development: R. Ng & E.X. Chen; Curr. Clin. Pharmacol. 1, 223 (2006)
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