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AdipoGen Life Sciences
MnTMPyP . pentachloride
40
CHF
CHF 40.00
In stock
AG-CR1-0026-M01010 mgCHF 40.00
AG-CR1-0026-M05050 mgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl- |
| Product Type | Chemical |
| Properties | |
| Formula |
C44H36MnN8Cl5 |
| MW | 909.0 |
| CAS | 100012-18-8 |
| Purity Chemicals | ≥95% |
| Appearance | Black solid. |
| Solubility | Soluble in aqueous base. |
| Other Product Data |
Prepare solutions immediately before experiments. We recommend using fresh preparations each day. |
| InChi Key | YFSTUYRXNOTFMB-UHFFFAOYSA-N |
| Smiles | C[N+]1=CC=C(C=C1)C1=C2C=CC3=[N]2C24N5C1=CC=C5C(=C1C=CC(C(=C5C=CC(N25)=C3C2=CC=[N+](C)C=C2)C2=CC=[N+](C)C=C2)=[N]41)C1=CC=[N+](C)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable superoxide dismutase (SOD) mimetic [1, 2, 4].
- Peroxynitrite scavenger [3].
- Displays a protective effect against H2O2 mediated injury [5].
- Neuroprotective [6].
- Oxidative stress inhibitor [7].
- Apoptosis inhibitor [7].
- Reduces inflammation [8].
Product References
- Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)
- Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996)
- Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998)
- The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998)
- Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells: B.E. Dwyer, et al.; J. Neurochem. 71, 2497 (1998)
- Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation: S.S. Sharma & S. Gupta; Eur. J. Pharmacol. 561, 72 (2007)
- MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion: H.L. Liang, et al.; Am. J. Physiol. Renal Physiol. 296, F266 (2009)
- MnTMPyP, a superoxide dismutase/catalase mimetic, decreases inflammatory indices in ischemic acute kidney injury: J. Mortensen, et al.; Inflamm. Res. 60, 299 (2011)