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AdipoGen Life Sciences
SB203580
45
CHF
CHF 45.00
In stock
AG-CR1-0030-M0011 mgCHF 45.00
AG-CR1-0030-M0055 mgCHF 115.00
AG-CR1-0030-M02525 mgCHF 440.00
| Product Details | |
|---|---|
| Synonyms | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H16FN3OS |
| MW | 377.4 |
| CAS | 152121-47-6 |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or methanol. |
| InChi Key | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| Smiles | C[S+]([O-])C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, specific p38 MAP kinase inhibitor [1, 2, 5].
- Binds to the ATP binding site of p38 MAP kinase [3].
- T cell proliferation inhibitor [4].
- IL-2 production inhibitor [4].
- SAPK/JNK inhibitor [5].
- COX-1 and -2 inhibitor [6].
- Raf-1 activator [7, 8].
- Apoptosis enhancer [9].
- Antiproliferative [10].
- PDK1 inhibitor [10].
- Anti-inflammatory [11].
- Review [12].
- Enhances cardiomyogenesis of human embryonic stem cells (hESCs) [13].
Product References
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett. 364, 229 (1995)
- Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997)
- Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site: P.R. Young, et al.; J. Biol. Chem. 272, 12116 (1997)
- A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production: S.G. Ward, et al.; Biochem. Soc. Trans. 25, 304S (1997)
- The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs): A. Clerk & P.H. Sugden; FEBS Lett. 426, 93 (1998)
- Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase: A.G. Börsch-Haubold, et al.; J. Biol. Chem. 273, 28766 (1998)
- Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580: A. Kalmes, et al.; FEBS Lett. 444, 71 (1999)
- Effect of SB 203580 on the activity of c-Raf in vitro and in vivo: C.A. Hall-Jackson, et al.; Oncogene 18, 2047 (1999)
- SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils: H. Kankaanranta, et al.; J. Pharmacol. Exp. Ther. 290, 621 (1999)
- The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mit: F.V. Lali, et al.; J. Biol. Chem. 275, 7395 (2000)
- SB203580, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model: W.D. Zhou, et al.; Hum. Reprod. 25, 3110 (2010)
- p38 MAP-kinases pathway regulation, function and role in human diseases: A. Cuenda & S. Rousseau; Biochim. Biophys. Acta 1773, 1358 (2007)
- Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells: H. Kempf, et al.; Stem Cell Res. 7, 198 (2011)
- Hypoxia/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signaling: Y. Cheng, et al. Biochim. Biophys. Acta 1863, 354 (2017)
- Palmitic acid induces guanylin gene expression through the toll-like receptor 4/nuclear factor κB pathway in rat macrophages: S. Akieda-Asai, et al.; Am. J. Cell Physiol. ahead of print (2019)
- Extracellular stimulation of lung fibroblasts with arachidonic acid increases interleukin 11 expression through p38 and ERK signaling: K. Sasaki, et al.; Biol. Chem. ahead of print (2022)