AG-CR1-0036-M0011 mgCHF 80.00
AG-CR1-0036-M0055 mgCHF 320.00
|Purity Chemicals||≥98% (NMR)|
|Appearance||Yellow to brown powder.|
|Solubility||Soluble in DMSO; insoluble in water or 100% ethanol.|
|Identity||Determined by IR, 1H-NMR and 13C-NMR.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
|Handling Advice||Protect from light.|
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
- Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor .
- Anti-tumor compound 
- Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM) [2, 4].
- GSK-3β (glycogen synthase kinase-3β) inhibitor [2, 3].
- Apoptosis inhibitor [6, 7].
- Apoptosis inducer .
- Angiogenesis inhibitor .
- Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2909 (1999)
- Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000)
- Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor: M. Knockaert, et al.; J. Biol. Chem. 277, 25493 (2002)
- The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)
- Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential: T. Lahusen, et al.; Mol Carcinog 36, 183 (2003)
- Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Neurosci. Lett. 408, 124
- Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Cell. Mol. Neurobiol. 30, 863 (2010)
- Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro: S. Zahler, et al.; Angiogenesis 13, 239 (2010)