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AdipoGen Life Sciences
Pifithrin-α (cyclic) . hydrobromide
70
CHF
CHF 70.00
In stock
AG-CR1-0052-M0055 mgCHF 70.00
AG-CR1-0052-M01010 mgCHF 120.00
AG-CR1-0052-M05050 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole . HBr; beta-Pifithrin; PFT-beta; QB102 |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H16N2S . HBr |
| MW | 268.4 . 80.9 |
| CAS |
511296-88-1 60477-34-1 (free base) |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO. |
| InChi Key | SGNCOAOESGSEOP-UHFFFAOYSA-N |
| Smiles | [Br].CC1=CC=C(C=C1)C1=CN2C(SC3=C2CCCC3)=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Stable analog of pifithrin-α [1].
- p53 inhibitor [1, 2].
Product References
- Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies: Bioorg. Med. Chem. Lett. 15, 1561 (2005)
- Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism: N. Pietrancosta, et al.; J. Med. Chem. 49, 3645 (2006)
- Loss of Fragile X Protein FMRP Impairs Homeostatic Synaptic Downscaling through Tumor Suppressor p53 and Ubiquitin E3 Ligase Nedd4-2: K.Y. Lee, et al.; Hum. Mol. Genet. ahead of print (2018)