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AdipoGen Life Sciences
Robotnikinin
390
CHF
CHF 390.00
In stock
AG-CR1-0069-M0011 mgCHF 390.00
| Product Details | |
|---|---|
| Synonyms | N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2- phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H27ClN2O4 |
| MW | 454.9 |
| CAS | 1132653-79-2 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | >95% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DRDSZZCLAHXSAE-BQIDRLATSA-N |
| Smiles | ClC1=CC=C(CNC(=O)C[C@@H]2C\C=C\CCC(=O)O[C@@H](CNC2=O)C2=CC=CC=C2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Sonic hedgehog (Shh) signaling modulator [1, 2, 3].
- Inhibits the Shh pathway in human cell lines upstream of Smo [1, 2, 3].
- Targets the Shh N-terminal protein [1, 2, 3].
Product References
- A small molecule that binds Hedgehog and blocks its signaling in human cells: B.Z. Stanton, et al.; Nat. Chem. Biol. 5, 154 (2009)
- Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog: L.F. Peng, et al.; Bioorg. Med. Chem. Lett. 19, 6319 (2009)
- Small-molecule modulators of the Sonic Hedgehog signaling pathway: B.Z. Stanton & L.F. Peng; Mol. Biosyst. 6, 44 (2010) (Review)
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