LY-294,002

CHF 45.00
In stock
AG-CR1-0108-M0011 mgCHF 45.00
AG-CR1-0108-M0055 mgCHF 85.00
AG-CR1-0108-M02525 mgCHF 340.00
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Product Details
Synonyms 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Product Type Chemical
Properties
Formula C19H17NO3
MW 307.4
CAS 154447-36-6
Purity Chemicals ≥99% (NMR)
Appearance White to off-white crystalline solid.
Solubility Soluble in DMSO, 100% ethanol or methanol.
Identity Determined by 1H-NMR.
InChi Key CZQHHVNHHHRRDU-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor.
  • pan-class I / II / III PI3K inhibitor.
  • Acts on the ATP-binding site of the enzyme.
  • In solution more stable than wortmannin.
  • Antagonizes P-glycoprotein-mediated multidrug resistance.
  • Blocks Akt phosphorylation.
  • Pim-1 kinase inhibitor.
  • Autophagy inhibitor (autophagosome formation).
  • Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
Product References
  1. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002): C.J. Vlahos, et al.; J. Biol. Chem. 269, 5241 (1994)
  2. Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase: C.J. Vlahos, et al.; J. Immunol. 154, 2413 (1995)
  3. Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005)
  4. LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh & S. Pervaiz; Cancer Res. 65, 6264 (2005)
  5. LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance: M. Barancík, et al.; Eur. J. Pharm. Sci. 29, 426 (2006)
  6. A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder: F.J. Tamarkin, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 373, 349 (2006)
  7. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 15, 5837 (2007)
  8. The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains: A. Dittmann, et al.; ACS Chem. Biol. 9, 495 (2014)
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