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AdipoGen Life Sciences
LY-294,002
30
CHF
CHF 30.00
In stock
AG-CR1-0108-M0011 mgCHF 30.00
AG-CR1-0108-M0055 mgCHF 50.00
AG-CR1-0108-M02525 mgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C19H17NO3 |
| MW | 307.4 |
| CAS | 154447-36-6 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | White to off-white crystalline solid. |
| Solubility | Soluble in DMSO, 100% ethanol or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCOCC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor.
- pan-class I / II / III PI3K inhibitor.
- Acts on the ATP-binding site of the enzyme.
- In solution more stable than wortmannin.
- Antagonizes P-glycoprotein-mediated multidrug resistance.
- Blocks Akt phosphorylation.
- Pim-1 kinase inhibitor.
- Autophagy inhibitor (autophagosome formation).
- Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
- Angiogenesis inhibitor.
Product References
- A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002): C.J. Vlahos, et al.; J. Biol. Chem. 269, 5241 (1994)
- Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase: C.J. Vlahos, et al.; J. Immunol. 154, 2413 (1995)
- Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005)
- LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh & S. Pervaiz; Cancer Res. 65, 6264 (2005)
- LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance: M. Barancík, et al.; Eur. J. Pharm. Sci. 29, 426 (2006)
- A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder: F.J. Tamarkin, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 373, 349 (2006)
- Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 15, 5837 (2007)
- The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains: A. Dittmann, et al.; ACS Chem. Biol. 9, 495 (2014)
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