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AdipoGen Life Sciences
Bisindolylmaleimide XI . hydrochloride
100
CHF
CHF 100.00
In stock
AG-CR1-0109-M0011 mgCHF 100.00
AG-CR1-0109-M0055 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | Ro 32-0432; BIM XI |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H28N4O2 . HCl |
| MW | 452.5 . 36.5 |
| CAS | 145333-02-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Dark red solid. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HSPRASOZRZDELU-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CC1CCN2C(C1)=C(C1=C2C=CC=C1)C1=C(C(=O)NC1=O)C1=CN(C)C2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective cell permeable protein kinase C (PKC) inhibitor.
- G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor.
- Prevents T cell-driven chronic inflammatory responses in vivo.
Product References
- Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation: A.M. Birchall, et al.; J. Pharmacol. Exp. Ther. 268, 922 (1994)
- Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
- Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development: P.G. Goekjian & M.R. Jirousek; Curr. Med. Chem. 6, 877 (1999) (Review)
- Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors: N. Aiyar, et al.; Eur. J. Pharmacol. 403, 1 (2000)
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