AdipoGen Life Sciences

Bisindolylmaleimide XI . hydrochloride

CHF 100.00
In stock
AG-CR1-0109-M0011 mgCHF 100.00
AG-CR1-0109-M0055 mgCHF 320.00
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Product Details
Synonyms Ro 32-0432; BIM XI
Product Type Chemical
Properties
Formula

C28H28N4O2 . HCl

MW 452.5 . 36.5
CAS 145333-02-4
Purity Chemicals ≥98% (HPLC)
Appearance Dark red solid.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
InChi Key HSPRASOZRZDELU-UHFFFAOYSA-N
Smiles Cl.CN(C)CC1CCN2C(C1)=C(C1=C2C=CC=C1)C1=C(C(=O)NC1=O)C1=CN(C)C2=C1C=CC=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Selective cell permeable protein kinase C (PKC) inhibitor.
  • G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor.
  • Prevents T cell-driven chronic inflammatory responses in vivo.
Product References
  1. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation: A.M. Birchall, et al.; J. Pharmacol. Exp. Ther. 268, 922 (1994)
  2. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
  3. Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development: P.G. Goekjian & M.R. Jirousek; Curr. Med. Chem. 6, 877 (1999) (Review)
  4. Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors: N. Aiyar, et al.; Eur. J. Pharmacol. 403, 1 (2000)
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