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AdipoGen Life Sciences
PD 98,059
25
CHF
CHF 25.00
In stock
AG-CR1-0118-M0011 mgCHF 25.00
AG-CR1-0118-M0055 mgCHF 80.00
AG-CR1-0118-M01010 mgCHF 120.00
AG-CR1-0118-M05050 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | PD 98059, 2'-Amino-3'-methoxyflavone |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H13NO3 |
| MW | 267.3 |
| CAS | 167869-21-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Yellow solid. |
| Solubility | Soluble in anhydrous DMSO, methanol or dichloromethane. Slightly soluble in ethanol. |
| InChi Key | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
| Smiles | COC1=C(N)C(=CC=C1)C1=CC(=O)C2=CC=CC=C2O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor [1-3, 7].
- Blocks the phosphorylation and activation of the MAP kinase pathway [1-3, 7].
- T cell activation inhibitor [4].
- Inhibits cell growth and cell proliferation of several cancer cells [5, 6, 8].
Product References
- A synthetic inhibitor of the mitogen-activated protein kinase cascade: D.T. Dudley, et al.; PNAS 92, 7686 (1995)
- Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor: L. Pang, et al.; J. Biol. Chem. 270, 13585 (1995)
- PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo: D. Alessi, et al.; J. Biol. Chem. 270, 27489 (1995)
- Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production: F.J. Dumont, et al.; J. Immunol. 160, 2579 (1998)
- A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts: M. Tresini, et al.; Cancer Res. 58, 1 (1998)
- PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma: C. Simon, et al.; Br. J. Cancer 80, 1412 (1999)
- Specificity and mechanism of action of some commonly used protein kinase inhibitors. S.P. Davies, et al.; Biochem. J. 351, 95 (2000)
- Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells: K. Kojima, et al.; Cancer Res. 67, 3210 (2007)