α-NETA

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Product Details
Synonyms	2-(α-Naphthoyl)ethyltrimethylammonium iodide
Product Type	Chemical
Properties
Formula	C₁₆H₂₀INO
MW	369.2
CAS	31059-54-8
Purity Chemicals	≥97% (NMR)
Appearance	White to off-white solid.
Solubility	Soluble in methanol or DMSO (3mg/ml). Sparingly soluble in water.
Identity	Determined by ¹H-NMR.
Other Product Data	Handling Note: 1. The product is not very stable in solution and should not be heated during dissolution. We recommend to use freshly prepared solutions. 2. A stock solution in abs. methanol can be made. Further dilute the stock solution in aqueous buffers. If performing biological experiments, ensure the residual amount of methanol is insignificant (<0.1%), since it may have physiological effects at low concentrations.
InChi Key	QZXMJYVXMZJOAO-UHFFFAOYSA-M
Smiles	[I-].C[N+](C)(C)CCC(=O)C1=C2C=CC=CC2=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Potent fluorescent inhibitor of choline acetyltransferase.
CMKLR1 antagonist. Inhibits chemerin-stimulated β-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration.
Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.

Product References

2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase: B.V. Sastry, et al.; J. Pharmacol. Exp. Ther. 245, 72 (1988)
Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyl trimethylammonium and related compounds: B.V. Sastry, et al.; Pharmacol. Res. Commun. 20, 751 (1988)
Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells: B.M Eaton & S.R. Sooranna; Placenta 19, 663 (1998)
Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells: D.A. Sawatzky, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 285, L1296 (2003)
A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease: K.L. Graham, et al.; PLoS One 9, e112925 (2014)

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