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AdipoGen Life Sciences
MAC-545496
90
CHF
CHF 90.00
In stock
AG-CR1-0163-M0011 mgCHF 90.00
AG-CR1-0163-M0055 mgCHF 270.00
AG-CR1-0163-M02525 mgCHF 750.00
| Product Details | |
|---|---|
| Synonyms | N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C18H18ClN5O3S |
| MW | 419.9 |
| CAS | 838810-96-1 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, ethanol, methanol or dichloromethane. |
| Identity | Determined by 1H-NMR. |
| InChi Key | AFOKREIUUQFDNW-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(NC(C2=CC([N+]([O-])=O)=C(N3CCCCC3)C=C2)=O)=S)N=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
-
MAC-545496 is a potent antimicrobial agent against MRSA. It works as a synthetic antibiotic adjuvant, a antivirulence and antibiofilm agent.
- Potent nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), a regulator of the cell-envelope stress response that is an important virulence factor and determinant of antibiotic resistance.
- Antivirulence compound that reverses β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) strains. MAC-545496 cripples MRSA’s ability to cause infection by diminishing its tolerance to the hostile components of the immune system and blocking the bacterium’s capacity to resist the action of several front-line antibiotics.
- Inhibits biofilm formation and abrogates intracellular survival in macrophages.
- MAC-545496 targets the bacteria in several different ways, it makes MRSA more susceptible to attack from the immune system, renders it vulnerable to the action of several antibiotics again and reduces the bacteria’s ability to produce biofilms.
Product References
- Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA: O.M. El-Halfawy, et al.; Nat. Chem. Biol. 16, 143 (2020)
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