Shz-1

Specifications / Handling

More Information

Product Details
Synonyms	Sulfonylhydrazone-1; 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide benzenesulfonic acid
Product Type	Chemical
Properties
Formula	C13H11BrN2O3S
MW	355.2
CAS	326886-05-9
Purity Chemicals	≥95% (NMR)
Appearance	White to yellow solid.
Solubility	Soluble in DMSO (at least 5 mg/ml).
InChi Key	OEMCLQLAWYKPRK-OQLLNIDSSA-N
Smiles	OC1=C(\C=N\NS(=O)(=O)C2=CC=CC=C2)C=C(Br)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

• Enhancer of myocardial regenerative repair by stem cells [1].
• Potent inducer of Homeobox protein Nkx2.5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SαTM) in a variety of different stem/progenitor cells [1].

Product-specific References

1. Cardiogenic small molecules that enhance myocardial repair by stem cell: H. Sadek, et al.; PNAS 105, 6063 (2008) 
2. Synthetic sulfonyl-hydrazone-1 positively regulates cardiomyogenic microRNA expression and cardiomyocyte differentiation of induced pluripotent stem cells: M. Quattrocelli, et al.; J. Cell Biochem. 112, 2006 (2011)
3. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule: Ch. Nan, et al.; Cardiovasc. Toxicol. 15, 29 (2015)