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AdipoGen Life Sciences
SMI-4a
85
CHF
CHF 85.00
In stock
AG-CR1-3503-M0055 mgCHF 85.00
| Product Details | |
|---|---|
| Synonyms | PIM1/2 Kinase Inhibitor V; (5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H6F3NO2S |
| MW | 273.2 |
| CAS | 327033-36-3 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (at least 5 mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| Smiles | FC(F)(F)C1=CC(\C=C2/SC(=O)NC2=O)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective inhibitor of Pim-1 and Pim-2 protein kinases [1-5].
- Inducer of G1 phase cell cycle arrest [1-5].
- Inducer of p27Kip1 [1-5].
- Inducer of apoptosis through the mitochondrial pathway [1-5].
- Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway [1-5].
- Downregulates c-myc [1-5].
- Inhibitor of PRAS40 phosphorylation and mTOR activity [1-5].
- Potential anti-cancer compound [2,4,5].
- Blocks prostate cancer growth [2,4,5].
- Suppressor of cytokines production in lipopolysaccharide (LPS)-induced acute lung injury (ALI)
Product References
- Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases: Z. Xia, et al.; J. Med. Chem. 52, 74 (2009)
- Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells: Z. Beharry, et al.; Mol. Cancer Ther. 8, 1473 (2009)
- PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells: F. Zhang, et al.; Cancer Biol. Ther. 8, 846 (2009)
- A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma: Y.-W. Lin, et al.; Blood 115, 824 (2010)
- Regulation of Skp2 levels by the Pim-1 protein kinase: B. Cen, et al.; JBC 285, 29128 (2010)
- PIM1 inhibitor SMI-4a attenuated lipopolysaccharide-induced acute lung injury through suppressing macrophage inflammatory responses via modulating p65 phosphorylation: J. Wang, et al.; Int. Immunopharm. 73, 568 (2019)