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AdipoGen Life Sciences
Ds(+)-threo-Isocitric acid . trisodium salt
80
CHF
CHF 80.00
In stock
AG-CR1-3505-M02525 mgCHF 80.00
AG-CR1-3505-M100100 mgCHF 240.00
AG-CR1-3505-G0011 gCHF 1'680.00
| Product Details | |
|---|---|
| Synonyms | (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid . trisodium salt |
| Product Type | Chemical |
| Properties | |
| Formula |
C6H5O7 . 3Na |
| MW | 189.1 . 69.0 |
| CAS | 903507-52-8 | Free Acid: 6061-97-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water. |
| Identity | Determined by 1H-NMR. Iron-free. |
| InChi Key | HWMVXEKEEAIYGB-UHFFFAOYSA-K |
| Smiles | O[C@H]([C@H](CC(=O)O[Na])C(=O)O[Na])C(=O)O[Na] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep under inert gas. Protect from light. Protect from moisture and oxygen. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticoagulant that retains platelets functionality.
- Buffers Ca2+ activity in physiological range (~1mM).
- Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response.
- Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness.
- Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome.
- Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.
Product References
- Isocitrate as Calcium Ion Activity Buffer in Coagulation Assays: M. Ranby, et al.; Clin. Chem. 45, 1176 (1999)
- Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2R,3S)-Isocitric Acid by Fermentation of Sunflower Oil: P. Heretsch, et al.; Angew. Chem. Int. Ed. 47, 1958 (2008)
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate: L. Dang, et al.; Nature 462, 739 (2009)
- Iron control of erythroid development by a novel aconitase-associated regulatory pathway: G.C. Bullock, et al.; Blood 116, 97 (2010)