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AdipoGen Life Sciences
S14161
70
CHF
CHF 70.00
In stock
AG-CR1-3516-M0011 mgCHF 70.00
AG-CR1-3516-M0055 mgCHF 280.00
| Product Details | |
|---|---|
| Synonyms | 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran; 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H14FNO4 |
| MW | 315.3 |
| CAS | 883046-50-2 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR and HR-MS. |
| InChi Key | FZXDHIUPNWOMT-UHFFFAOYSA-N |
| Smiles | CCOC1=C2OC(C3=CC=C(F)C=C3)C(=CC2=CC=C1)[N+]([O-])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent antileukemia and antimyeloma compound [1].
- Apoptosis inducer [1].
- Delays tumor growth [1].
- Cyclin D2 promoter transactivation inhibitor [1].
- Inhibitor of pan-Class I PI3K isoforms [1,2].
Product References
- A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway: X. Mao, et al.; Blood 117, 1986 (2011)
- Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization: K. Han, et al.; J. Hematol. Oncol. 7, 1756 (2014)
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