Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
22-NHC . hydrochloride
80
CHF
CHF 80.00
In stock
AG-CR1-3523-M0011 mgCHF 80.00
AG-CR1-3523-M0055 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | 22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H45NO . HCl |
| MW | 387.6 . 36.5 |
| CAS | 360068-87-7 or 3915-24-0 (free base) |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | GDMMRLCQKPSXQG-USNJAYOWSA-N |
| Smiles | [Cl-].[H][C@@]12CC[C@H]([C@H](C)[NH2+]CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Aza-steroid [1].
- Hedgehog signaling inhibitor [1].
- Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo) [1].
- For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524).
Product References
- Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9, 557 (2013)