AdipoGen Life Sciences

2'-Deoxy-5-formylcytidine

Name: 2'-Deoxy-5-formylcytidine
Brand: AdipoGen Life Sciences
SKU: AG-CR1-3531
Price: 65.00 CHF
Availability: InStock

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AG-CR1-3531-M0011 mgCHF 65.00

AG-CR1-3531-M0055 mgCHF 195.00

Specifications / Handling

More Information
Product Details
Synonyms	5-Formyl-2’-deoxycytididine; 5-Formyl-dC; 5-fC; 5-FoC
Product Type	Chemical
Properties
Formula	C₁₀H₁₃N₃O₅
MW	255.2
CAS	137017-45-9
Purity Chemicals	≥98%
Appearance	White solid.
Solubility	Soluble in DMSO (10mg/ml) or water.
Identity	Determined by ¹H-NMR.
InChi Key	QBADNGFALQJSIH-XLPZGREQSA-N
Smiles	O[C@H]1C[C@H](N2C=C(C([H])=O)C(N)=NC2=O)O[C@@H]1CO
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Hygroscopic. Keep cool and dry. Protect from moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Epigenetic base.
A minor nucleotide found in DNA and produced by UV or γ-mediated oxidation of the nucleoside 5-Methyl-2'-deoxycytidine. This nucleoside derivative was found in embryonic stem cell DNA.
Mutagenic and can induce 5-fC >> T transition mutation as well as the 5-fC >> A and 5-fC >> G transversion mutations during DNA synthesis, particularly in methylated CpG regions.
Used in epigenetic research and important for cancer research.

Product-specific References

Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation: N. Murata-Kamiya, et al.; Nucleic Acids Res. 27, 4385 (1999)
Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine: N. Karino, et al.; Nucleic Acids Res. 29, 2456 (2001)
The discovery of 5-formylcytosine in embryonic stem cell DNA: T. Pfaffeneder, et al.; Angew. Chem. Int. Edit. 50, 7008 (2011)
A.S. Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine: Schroeder, et al.; Angew. Chem. Int. Ed. 53, 315 (2014)
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer; M. Zauri, et al.; Nature 524, 114 (2015)

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