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AdipoGen Life Sciences
2'-Deoxy-5-formylcytidine
65
CHF
CHF 65.00
In stock
AG-CR1-3531-M0011 mgCHF 65.00
AG-CR1-3531-M0055 mgCHF 195.00
| Product Details | |
|---|---|
| Synonyms | 5-Formyl-2’-deoxycytididine; 5-Formyl-dC; 5-fC; 5-FoC |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H13N3O5 |
| MW | 255.2 |
| CAS | 137017-45-9 |
| Purity Chemicals | ≥98% |
| Appearance | White solid. |
| Solubility | Soluble in DMSO (10mg/ml) or water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | QBADNGFALQJSIH-XLPZGREQSA-N |
| Smiles | O[C@H]1C[C@H](N2C=C(C([H])=O)C(N)=NC2=O)O[C@@H]1CO |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep cool and dry. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Epigenetic base.
- A minor nucleotide found in DNA and produced by UV or γ-mediated oxidation of the nucleoside 5-Methyl-2'-deoxycytidine. This nucleoside derivative was found in embryonic stem cell DNA.
- Mutagenic and can induce 5-fC >> T transition mutation as well as the 5-fC >> A and 5-fC >> G transversion mutations during DNA synthesis, particularly in methylated CpG regions.
- Used in epigenetic research and important for cancer research.
Product References
- Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation: N. Murata-Kamiya, et al.; Nucleic Acids Res. 27, 4385 (1999)
- Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine: N. Karino, et al.; Nucleic Acids Res. 29, 2456 (2001)
- The discovery of 5-formylcytosine in embryonic stem cell DNA: T. Pfaffeneder, et al.; Angew. Chem. Int. Edit. 50, 7008 (2011)
- A.S. Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine: Schroeder, et al.; Angew. Chem. Int. Ed. 53, 315 (2014)
- CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer; M. Zauri, et al.; Nature 524, 114 (2015)
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