AdipoGen Life Sciences


CHF 65.00
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AG-CR1-3531-M0011 mgCHF 65.00
AG-CR1-3531-M0055 mgCHF 195.00
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Product Details
Synonyms 5-Formyl-2’-deoxycytididine; 5-Formyl-dC; 5-fC; 5-FoC
Product Type Chemical


MW 255.2
CAS 137017-45-9
Purity Chemicals ≥98%
Appearance White solid.
Solubility Soluble in DMSO (10mg/ml) or water.
Identity Determined by 1H-NMR.
Smiles O[C@H]1C[C@H](N2C=C(C([H])=O)C(N)=NC2=O)O[C@@H]1CO
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Hygroscopic.
Keep cool and dry.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Epigenetic base.
  • A minor nucleotide found in DNA and produced by UV or γ-mediated oxidation of the nucleoside 5-Methyl-2'-deoxycytidine. This nucleoside derivative was found in embryonic stem cell DNA.
  • Mutagenic and can induce 5-fC >> T transition mutation as well as the 5-fC >> A and 5-fC >> G transversion mutations during DNA synthesis, particularly in methylated CpG regions.
  • Used in epigenetic research and important for cancer research.
Product References
  1. Formation of 5-formyl-2'-deoxycytidine from 5-methyl-2'-deoxycytidine in duplex DNA by Fenton-type reactions and gamma-irradiation: N. Murata-Kamiya, et al.; Nucleic Acids Res. 27, 4385 (1999)
  2. Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine: N. Karino, et al.; Nucleic Acids Res. 29, 2456 (2001)
  3. The discovery of 5-formylcytosine in embryonic stem cell DNA: T. Pfaffeneder, et al.; Angew. Chem. Int. Edit. 50, 7008 (2011)
  4. A.S. Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine: Schroeder, et al.; Angew. Chem. Int. Ed. 53, 315 (2014)
  5. CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer; M. Zauri, et al.; Nature 524, 114 (2015)
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